Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 361104..361894 Replicon plasmid unnamed1
Accession NZ_CP064188
Organism Rhizobium sp. 007

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag ISN39_RS22745 Protein ID WP_194730543.1
Coordinates 361397..361894 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag ISN39_RS22740 Protein ID WP_194730542.1
Coordinates 361104..361400 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISN39_RS22715 356772..357788 - 1017 WP_194730538.1 taurine ABC transporter substrate-binding protein -
ISN39_RS22720 358055..358540 + 486 WP_194730539.1 AAA family ATPase -
ISN39_RS22725 358720..358932 + 213 WP_194730540.1 hypothetical protein -
ISN39_RS22730 358983..359974 - 992 Protein_347 hypothetical protein -
ISN39_RS22735 360101..360574 - 474 WP_194730541.1 VOC family protein -
ISN39_RS22740 361104..361400 + 297 WP_194730542.1 DUF1778 domain-containing protein Antitoxin
ISN39_RS22745 361397..361894 + 498 WP_194730543.1 GNAT family N-acetyltransferase Toxin
ISN39_RS22750 362018..362399 - 382 Protein_351 type II toxin-antitoxin system VapC family toxin -
ISN39_RS22755 362396..362596 - 201 WP_028739294.1 type II toxin-antitoxin system VapB family antitoxin -
ISN39_RS22760 363256..363699 + 444 WP_194730544.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit -
ISN39_RS22765 363699..365090 + 1392 WP_194730545.1 acetyl-CoA carboxylase biotin carboxylase subunit -
ISN39_RS22770 365087..365515 + 429 WP_194730546.1 acetyl-CoA carboxylase -
ISN39_RS22775 365512..366219 + 708 WP_194730547.1 5-oxoprolinase subunit PxpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA / htpB 1..2277229 2277229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-142)

Antitoxin

Vibrio phage ICP1, Orf50

(7-97)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17809.51 Da        Isoelectric Point: 9.0370

>T180442 WP_194730543.1 NZ_CP064188:361397-361894 [Rhizobium sp. 007]
VTLSAPTPLADHHELAEFISGVVELDDWLRRRARANQAGGASRTFVVCEGNRVIAYYALASGAVKQPEAPGRFRRNMPDP
IPVAVLGRLAIDRTFQGRGLGRALVRDAGLRLLNAAEILGIRGVLVHAISDDARAFYEAVGFLPSPSDPMMLMVGLRDLN
NALNP

Download         Length: 498 bp

>T180442 NZ_CP085345:1372298-1373170 [Cupriavidus sp. MP-37]
ATGATTAGCAACCTCGCCGAGTCGGTGCGCGCGCGATTGCTGAACATCGCCAAAGCGCAAAAGGCGGACTTCAACCAGGT
GCTGGTGCGTTATGCGCTGGAGCGCATGCTCTATCGGTTAAGCCAGTCGCCGCATGGCGAGCGCTTTGTGCTCAAAGGCG
CTTTGCTGTTCACGCTCTGGTACGACATGCCGCATCGCGCTACCCGCGATGCCGACTTCCTTGGTTTCGGAGCGAGCGAT
CTGGCGTCGATCGCGAGAACGTTCCGGGACATCGCCGCTGTCAGTGCCGACGATGGCATGACATTCGATCCGGCATCGGT
GACCACGGAGGAAATTCGCAAGGAGGCGGGCTACGCCGGCGCGCGCGTCTTGCTTACCGGGGAACTGGCGCGGGCACAAT
GCCGGGTGCAAGTCGATATCGGATTTGGTGATGCCATCACGCCGGGGCCGGTCGACGCCATCTATCCGGTTCTGCTCGAT
GATCTGCCGGCGCCGCGGCTACGCGCATATCCGGTTTACACGGTCGTTTCCGAAAAACTGCATGCCATTGCGTTGCTTGG
CATGGCGAACAGCAGGCTAAAGGACTATTTCGATCTGGCTATCCTGCTGGGTCGCGAGACTCTTGATGCAGAGACCCTCG
CAAGCGCGGTGGCAGCGACTTTCATCAGACGCGGCATGACGGTTCCCGGTGCGTTGCCGCTTGGACTCACCGAAGAATTC
TCCACGGATTCGTCGCGGCAGGCGCTGTGGCAAGCGTTTCTGAAGAAGAACTCGCTCACATGGGAAGGGCTGCCAGACAC
CGTTGCAGTGTTGCGAACGGTCCTGGAGCCGGTCCTGATTCGCGCCCGCGCGATCGCAGGTCAGCAAGGCTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11070.61 Da        Isoelectric Point: 7.0159

>AT180442 WP_194730542.1 NZ_CP064188:361104-361400 [Rhizobium sp. 007]
MPTSHTSKSADASVPLNIRIKPATRNLIDRAAELLGKTRTDFMLEASERRAEEVLLDRTIFTVSPELYAEYLARLDAPAQ
PNERLKRTMTTKAPWDEA

Download         Length: 297 bp

>AT180442 NZ_CP085345:1371750-1372301 [Cupriavidus sp. MP-37]
ATGCTGCGCCCCGCCGATCTCGACAATATCGAAGTCCCACGAGTCATCCTGAGCCGCATGGTCGGCGCCGGCCTGCTCGA
GAAAATCGATCGGGGCGTCTACCGACTGTCGAATGATCCCCGCTCGGAGCACGAGAGCCTGGCCGCCATTGCTACCAGGG
TGCCGCAAGCTGTCTTCTGCCTGCTGACAGCGCTCCAGTTCCATGGCCTGACCACGCAACTTCCGCGCGAAGTCTGGATT
GCGATGCCGCGAGGCAGTCATGCGCCAAGAATCGATTTCCCGCCGATCAAAATGATCCAGGTCGCCGACGATATCTTCTC
GGCAGGCATTGACGTGGTTGAGCGCGACGGGATTCCGCTGCGGGTCTATAGCGCCGCCAGAACGGTGGCAGATTGCTTCA
AGCACCGCAATAAGGTAGGCCTCGACGTGGCACTGGAAGCCCTCAGGGATGCGCGGGCACAGCAAAAGGCATCGGCGGAC
GACCTCTGGCGCTTTGCCAAGATTTGCCGTGTCGCCGACGTCATGCGCCCGTATCTTGAGGCTGTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References