180437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4011196..4011850 Replicon chromosome
Accession NZ_CP064180
Organism Citrobacter amalonaticus strain CA71

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag ISX58_RS19445 Protein ID WP_044254016.1
Coordinates 4011196..4011603 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag ISX58_RS19450 Protein ID WP_042322123.1
Coordinates 4011584..4011850 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX58_RS19425 4007101..4008834 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
ISX58_RS19430 4008840..4009553 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISX58_RS19435 4009577..4010473 - 897 WP_194694114.1 site-specific tyrosine recombinase XerD -
ISX58_RS19440 4010574..4011095 + 522 WP_044254018.1 flavodoxin FldB -
ISX58_RS19445 4011196..4011603 - 408 WP_044254016.1 protein YgfX Toxin
ISX58_RS19450 4011584..4011850 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
ISX58_RS19455 4012107..4013087 + 981 WP_044254013.1 tRNA-modifying protein YgfZ -
ISX58_RS19460 4013168..4013827 - 660 WP_042999363.1 hemolysin III family protein -
ISX58_RS19465 4013990..4014301 - 312 WP_044254010.1 N(4)-acetylcytidine aminohydrolase -
ISX58_RS19470 4014354..4015082 + 729 WP_044254008.1 MurR/RpiR family transcriptional regulator -
ISX58_RS19475 4015202..4016635 + 1434 WP_044254006.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T180437 WP_044254016.1 NZ_CP064180:c4011603-4011196 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T180437 NZ_CP085344:2449035-2449325 [Cupriavidus sp. MP-37]
ATGCTCAGCATCCGCACCACCCAAACGTTTGACCGCTGGTACGCCGCCTTGCGCGACAGCGCTGCCAGGATTCGCATTCA
GGTCCGGATCGACCGCATGCTGAACGGAAATCCGGGCGACGTGAAAGCCCTTGGCGGTGGCATCTGTGAAATGCGGGTGG
ACCATGGTCCCGGCTACCGCATCTATTTTCAGCGATGCGGCGAAGTTCTTGTCATTCTCCTCTGCGGAGGCGACAAGTCG
ACCCAGCACGCTGATATCGGCCGGGGCACGCCACATGGCGGCGAACCTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT180437 WP_042322123.1 NZ_CP064180:c4011850-4011584 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT180437 NZ_CP085344:2449339-2449629 [Cupriavidus sp. MP-37]
ATGAAAGAACCAACCCGCCCTTGGGACTCGGCCGCACAACTGCGCAACGAAACGGAAATCGCCGCCTACCTGGACACCTG
CCTCGCCGAAGCCGGTGACGACGATCGTTTCATTGCCTACGCGCTCGGCGTGGTCGCGCGCGCCCGCGGCATGACGCGGC
TGGCCCGCGAAACCGGCCTGTCGCGCGAAAGCCTTTACCGTTCGCTGTCCGGCGAAGGCAATCCGGAGTTCGGGACCATC
TGGAAGGTGATGCGGGCGCTGGGAATTCGCCTGCATGCGAGCGTCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References