180419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4321878..4322535 Replicon chromosome
Accession NZ_CP064174
Organism Klebsiella pneumoniae strain 19110124

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ISU39_RS21130 Protein ID WP_002916310.1
Coordinates 4321878..4322288 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ISU39_RS21135 Protein ID WP_002916312.1
Coordinates 4322269..4322535 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU39_RS21110 4317878..4319611 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
ISU39_RS21115 4319617..4320330 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ISU39_RS21120 4320353..4321249 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ISU39_RS21125 4321350..4321871 + 522 WP_002916308.1 flavodoxin FldB -
ISU39_RS21130 4321878..4322288 - 411 WP_002916310.1 protein YgfX Toxin
ISU39_RS21135 4322269..4322535 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ISU39_RS21140 4322781..4323764 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ISU39_RS21145 4323915..4324574 - 660 WP_002916317.1 hemolysin III family protein -
ISU39_RS21150 4324738..4325049 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
ISU39_RS21155 4325099..4325827 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ISU39_RS21160 4325946..4327379 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T180419 WP_002916310.1 NZ_CP064174:c4322288-4321878 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T180419 NZ_CP085294:c209816-209715 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT180419 WP_002916312.1 NZ_CP064174:c4322535-4322269 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180419 NZ_CP085294:209593-209770 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References