Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1184795..1185414 Replicon chromosome
Accession NZ_CP064174
Organism Klebsiella pneumoniae strain 19110124

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISU39_RS05710 Protein ID WP_002892050.1
Coordinates 1184795..1185013 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISU39_RS05715 Protein ID WP_002892066.1
Coordinates 1185040..1185414 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU39_RS05675 1180842..1181105 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
ISU39_RS05680 1181105..1181245 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISU39_RS05685 1181242..1181940 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
ISU39_RS05690 1182041..1183492 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
ISU39_RS05695 1183467..1183937 - 471 WP_002892026.1 YlaC family protein -
ISU39_RS05700 1183958..1184098 + 141 WP_004147370.1 hypothetical protein -
ISU39_RS05705 1184070..1184636 - 567 WP_002892030.1 maltose O-acetyltransferase -
ISU39_RS05710 1184795..1185013 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISU39_RS05715 1185040..1185414 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISU39_RS05720 1185900..1189046 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
ISU39_RS05725 1189069..1190262 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T180409 WP_002892050.1 NZ_CP064174:c1185013-1184795 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T180409 NZ_CP085291:c751836-751720 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT180409 WP_002892066.1 NZ_CP064174:c1185414-1185040 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT180409 NZ_CP085291:751604-751809 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References