Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-Phd |
| Location | 1343498..1344071 | Replicon | chromosome |
| Accession | NZ_CP064173 | ||
| Organism | Vibrio cyclitrophicus strain ED008 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q5DZS7 |
| Locus tag | ISX50_RS21205 | Protein ID | WP_011263487.1 |
| Coordinates | 1343498..1343812 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B6ERG3 |
| Locus tag | ISX50_RS21210 | Protein ID | WP_012551865.1 |
| Coordinates | 1343817..1344071 (-) | Length | 85 a.a. |
Genomic Context
Location: 1338638..1339159 (522 bp)
Type: Others
Protein ID: WP_248375164.1
Type: Others
Protein ID: WP_248375164.1
Location: 1339156..1340952 (1797 bp)
Type: Others
Protein ID: WP_248398898.1
Type: Others
Protein ID: WP_248398898.1
Location: 1343080..1343349 (270 bp)
Type: Others
Protein ID: WP_248398904.1
Type: Others
Protein ID: WP_248398904.1
Location: 1347100..1347438 (339 bp)
Type: Others
Protein ID: WP_248398912.1
Type: Others
Protein ID: WP_248398912.1
Location: 1347800..1348189 (390 bp)
Type: Others
Protein ID: WP_248398914.1
Type: Others
Protein ID: WP_248398914.1
Location: 1341026..1342033 (1008 bp)
Type: Others
Protein ID: WP_248398900.1
Type: Others
Protein ID: WP_248398900.1
Location: 1342178..1342879 (702 bp)
Type: Others
Protein ID: WP_248398902.1
Type: Others
Protein ID: WP_248398902.1
Location: 1343498..1343812 (315 bp)
Type: Toxin
Protein ID: WP_011263487.1
Type: Toxin
Protein ID: WP_011263487.1
Location: 1343817..1344071 (255 bp)
Type: Antitoxin
Protein ID: WP_012551865.1
Type: Antitoxin
Protein ID: WP_012551865.1
Location: 1344154..1344245 (92 bp)
Type: Others
Protein ID: Protein_1110
Type: Others
Protein ID: Protein_1110
Location: 1344270..1344746 (477 bp)
Type: Others
Protein ID: WP_248398906.1
Type: Others
Protein ID: WP_248398906.1
Location: 1344902..1345621 (720 bp)
Type: Others
Protein ID: WP_248398908.1
Type: Others
Protein ID: WP_248398908.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISX50_RS21180 (ISX50_21150) | 1338638..1339159 | + | 522 | WP_248375164.1 | gluconokinase | - |
| ISX50_RS21185 (ISX50_21155) | 1339156..1340952 | + | 1797 | WP_248398898.1 | phosphogluconate dehydratase | - |
| ISX50_RS21190 (ISX50_21160) | 1341026..1342033 | - | 1008 | WP_248398900.1 | LacI family DNA-binding transcriptional regulator | - |
| ISX50_RS21195 (ISX50_21165) | 1342178..1342879 | - | 702 | WP_248398902.1 | lipoate--protein ligase | - |
| ISX50_RS21200 (ISX50_21170) | 1343080..1343349 | + | 270 | WP_248398904.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| ISX50_RS21205 (ISX50_21175) | 1343498..1343812 | - | 315 | WP_011263487.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| ISX50_RS21210 (ISX50_21180) | 1343817..1344071 | - | 255 | WP_012551865.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| ISX50_RS21215 (ISX50_21185) | 1344154..1344245 | - | 92 | Protein_1110 | DUF3265 domain-containing protein | - |
| ISX50_RS21220 (ISX50_21190) | 1344270..1344746 | - | 477 | WP_248398906.1 | GNAT family N-acetyltransferase | - |
| ISX50_RS21225 (ISX50_21195) | 1344902..1345621 | - | 720 | WP_248398908.1 | hypothetical protein | - |
| ISX50_RS21235 (ISX50_21205) | 1347100..1347438 | + | 339 | WP_248398912.1 | hypothetical protein | - |
| ISX50_RS21240 (ISX50_21210) | 1347800..1348189 | + | 390 | WP_248398914.1 | phage integrase N-terminal SAM-like domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1343080..1345621 | 2541 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12204.10 Da Isoelectric Point: 4.5467
>T180405 WP_011263487.1 NZ_CP064173:c1343812-1343498 [Vibrio cyclitrophicus]
MAVINWTESALLDLDEIAEYIAINNILAAKALVQSVFHRVERLEDFPLSGRSVPELPHLDYREIVLPPCRIFYKVTNDDI
VYILYVMREERELRQFVLNDRGLQ
MAVINWTESALLDLDEIAEYIAINNILAAKALVQSVFHRVERLEDFPLSGRSVPELPHLDYREIVLPPCRIFYKVTNDDI
VYILYVMREERELRQFVLNDRGLQ
Download Length: 315 bp
>T180405 NZ_CP085289:1562727-1563002 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9590.14 Da Isoelectric Point: 7.3180
>AT180405 WP_012551865.1 NZ_CP064173:c1344071-1343817 [Vibrio cyclitrophicus]
MKVELVTTLKRQATKILSELHASKEPVLITEHGQPSAYLLDVDDYEFMQKRIAILEGIARGEKAISDNRVVSHEVAKEKM
NKWL
MKVELVTTLKRQATKILSELHASKEPVLITEHGQPSAYLLDVDDYEFMQKRIAILEGIARGEKAISDNRVVSHEVAKEKM
NKWL
Download Length: 255 bp
>AT180405 NZ_CP085289:1562468-1562734 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA