Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1605163..1606727 Replicon chromosome
Accession NZ_CP064170
Organism Vibrio crassostreae strain ED395

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IS519_RS07200 Protein ID WP_248641100.1
Coordinates 1605411..1606727 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IS519_RS07195 Protein ID WP_248641098.1
Coordinates 1605163..1605411 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS519_RS07170 (IS519_07170) 1600838..1601860 + 1023 WP_248641088.1 DUF4238 domain-containing protein -
IS519_RS07175 (IS519_07175) 1602123..1602596 + 474 WP_248641090.1 DNA repair protein RadC -
IS519_RS07180 (IS519_07180) 1602593..1603021 + 429 WP_248641092.1 DUF2787 domain-containing protein -
IS519_RS07185 (IS519_07185) 1603071..1603511 + 441 WP_248641094.1 DUF2787 domain-containing protein -
IS519_RS07190 (IS519_07190) 1604088..1604423 + 336 WP_248641096.1 hypothetical protein -
IS519_RS07195 (IS519_07195) 1605163..1605411 + 249 WP_248641098.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IS519_RS07200 (IS519_07200) 1605411..1606727 + 1317 WP_248641100.1 type II toxin-antitoxin system HipA family toxin Toxin
IS519_RS07205 (IS519_07205) 1606857..1608737 - 1881 WP_248641101.1 RimK/LysX family protein -
IS519_RS07210 (IS519_07210) 1609043..1609852 - 810 WP_248641103.1 M15 family metallopeptidase -
IS519_RS07215 (IS519_07215) 1609935..1610663 - 729 WP_248641105.1 DUF429 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1573787..1606727 32940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49414.65 Da        Isoelectric Point: 7.0222

>T180404 WP_248641100.1 NZ_CP064170:1605411-1606727 [Vibrio crassostreae]
MQQLNAYMNGELVGTLTKQNNGSHEFKYNESWLSSDKSRPLSLSLKLQIPTITSDAVINYFDNLLPDNIAIRNRIVARYQ
TASNQPFDLLKEIGKDSVGAIALLPPSQPYIENKLSYELLDESRLEKILAAHHSDIPLGMIKEEDDFRISVAGAQEKTAL
LRLNGDWCLPKGNTPTSHIIKLPIGEIKQPTSILDLTESVENEFICIELARELGFDVPTVEIITTHNYKAIAVERFDRRW
IKDRTHLLRLPQEDICQAKGIPSSIKYESDGGPGIADIMKLLEGSSNALEDRYNFMKFQVFQWAIGAIDGHAKNYSIFIE
KQGSYRLTPFYDILSAYPITEKKGLNIRKLKLAMGLKASRGKKYQISKIYSRHFLDTAHSVGFNSDSMQSILDDMQTELP
KAIERLAARLPEGFPKHITEAIFDNSIAMLNKLNLGKN

Download         Length: 1317 bp

>T180404 NZ_CP085289:c1469061-1468966 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9386.82 Da        Isoelectric Point: 10.0981

>AT180404 WP_248641098.1 NZ_CP064170:1605163-1605411 [Vibrio crassostreae]
VIYSPQQLANTLLLIRQKNRWTQSELAKKVGIKQATISNFENRPEKATISTMFKLIQALDLTLKIEPKDVKNSQSTVGEE
DW

Download         Length: 249 bp

>AT180404 NZ_CP085289:1468866-1468931 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References