Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5382855..5383650 Replicon chromosome
Accession NZ_CP064167
Organism Escherichia coli O157:H7 strain Wll001

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag IMX21_RS26540 Protein ID WP_000854914.1
Coordinates 5383276..5383650 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag IMX21_RS26535 Protein ID WP_001280954.1
Coordinates 5382855..5383229 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMX21_RS26505 5378210..5379115 + 906 WP_000203541.1 chemotaxis protein -
IMX21_RS26510 5379112..5380182 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
IMX21_RS26515 5380522..5381340 + 819 WP_001234682.1 DUF945 domain-containing protein -
IMX21_RS26520 5381431..5381916 + 486 WP_000214398.1 antirestriction protein -
IMX21_RS26525 5381932..5382408 + 477 WP_001186738.1 RadC family protein -
IMX21_RS26530 5382471..5382692 + 222 WP_001220314.1 DUF987 domain-containing protein -
IMX21_RS26535 5382855..5383229 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IMX21_RS26540 5383276..5383650 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
IMX21_RS26545 5383647..5384138 + 492 WP_000976853.1 hypothetical protein -
IMX21_RS26550 5384150..5384347 + 198 WP_000839282.1 DUF957 domain-containing protein -
IMX21_RS26555 5384432..5385274 + 843 WP_001280481.1 DUF4942 domain-containing protein -
IMX21_RS26565 5385745..5386683 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
IMX21_RS26570 5386738..5387475 + 738 WP_000283664.1 zinc-binding phosphatase -
IMX21_RS26575 5387499..5388053 + 555 WP_001001917.1 molecular chaperone YcdY -
IMX21_RS26580 5388155..5388646 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T180401 WP_000854914.1 NZ_CP064167:5383276-5383650 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T180401 NZ_CP085289:c964766-964623 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT180401 WP_001280954.1 NZ_CP064167:5382855-5383229 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT180401 NZ_CP085289:964504-964690 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References