Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1152204..1152682 Replicon chromosome
Accession NZ_CP064167
Organism Escherichia coli O157:H7 strain Wll001

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag IMX21_RS06250 Protein ID WP_001303876.1
Coordinates 1152395..1152682 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag IMX21_RS06245 Protein ID WP_000536233.1
Coordinates 1152204..1152395 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMX21_RS06210 1147608..1148378 - 771 WP_000450992.1 DUF1627 domain-containing protein -
IMX21_RS06215 1148400..1149146 - 747 WP_000788751.1 ATP-binding protein -
IMX21_RS06220 1149153..1150244 - 1092 WP_001205823.1 hypothetical protein -
IMX21_RS06225 1150323..1150778 + 456 WP_000273724.1 hypothetical protein -
IMX21_RS06230 1150985..1151410 - 426 WP_000693855.1 Rha family transcriptional regulator -
IMX21_RS06235 1151394..1151666 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
IMX21_RS06240 1151775..1152176 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
IMX21_RS06245 1152204..1152395 + 192 WP_000536233.1 hypothetical protein Antitoxin
IMX21_RS06250 1152395..1152682 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMX21_RS06255 1152960..1153115 + 156 WP_000379575.1 DUF1391 family protein -
IMX21_RS06260 1153257..1153646 + 390 WP_000394511.1 hypothetical protein -
IMX21_RS06265 1153833..1154018 - 186 WP_001133046.1 hypothetical protein -
IMX21_RS06270 1154592..1154780 + 189 WP_000413705.1 cell division inhibition protein DicB -
IMX21_RS06275 1154777..1154968 + 192 WP_001098307.1 DUF1482 family protein -
IMX21_RS06280 1155062..1157533 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T180383 WP_001303876.1 NZ_CP064167:1152395-1152682 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T180383 NZ_CP085202:3497201-3497419 [Shigella flexneri]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT180383 WP_000536233.1 NZ_CP064167:1152204-1152395 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT180383 NZ_CP085202:3496801-3497175 [Shigella flexneri]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References