Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 689846..690317 | Replicon | chromosome |
| Accession | NZ_CP064167 | ||
| Organism | Escherichia coli O157:H7 strain Wll001 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | IMX21_RS03780 | Protein ID | WP_001303511.1 |
| Coordinates | 690039..690317 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | IMX21_RS03775 | Protein ID | WP_001302048.1 |
| Coordinates | 689846..690037 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IMX21_RS03735 | 685053..685637 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| IMX21_RS03740 | 685694..686089 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| IMX21_RS03745 | 686105..686874 | - | 770 | Protein_734 | DUF1627 domain-containing protein | - |
| IMX21_RS03750 | 686900..687640 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| IMX21_RS03755 | 687647..688609 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| IMX21_RS03760 | 688632..689057 | - | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| IMX21_RS03765 | 689054..689356 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| IMX21_RS03770 | 689454..689825 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| IMX21_RS03775 | 689846..690037 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| IMX21_RS03780 | 690039..690317 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IMX21_RS03785 | 690670..690969 | + | 300 | WP_001240334.1 | hypothetical protein | - |
| IMX21_RS03790 | 691041..691259 | + | 219 | WP_001171930.1 | hypothetical protein | - |
| IMX21_RS03795 | 691828..692016 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| IMX21_RS03800 | 692013..692204 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| IMX21_RS03805 | 692297..694768 | + | 2472 | WP_062946113.1 | exonuclease | - |
| IMX21_RS03810 | 694841..695092 | + | 252 | WP_000005552.1 | excisionase family protein | - |
| IMX21_RS03815 | 695127..695314 | + | 188 | Protein_748 | DUF3596 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 652026..697478 | 45452 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T180374 WP_001303511.1 NZ_CP064167:690039-690317 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T180374 NZ_CP085202:693111-693425 [Shigella flexneri]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT180374 WP_001302048.1 NZ_CP064167:689846-690037 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT180374 NZ_CP085202:693422-693838 [Shigella flexneri]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|