Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4332222..4332738 Replicon chromosome
Accession NZ_CP064129
Organism Klebsiella pneumoniae strain M911-1

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag IOD52_RS21225 Protein ID WP_009309309.1
Coordinates 4332454..4332738 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IOD52_RS21220 Protein ID WP_002886901.1
Coordinates 4332222..4332464 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD52_RS21205 4328250..4328990 + 741 WP_032417761.1 KDGP aldolase family protein -
IOD52_RS21210 4329057..4330211 + 1155 WP_002886900.1 lactonase family protein -
IOD52_RS21215 4330234..4332144 + 1911 WP_194524017.1 BglG family transcription antiterminator -
IOD52_RS21220 4332222..4332464 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IOD52_RS21225 4332454..4332738 + 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD52_RS21230 4332742..4333206 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IOD52_RS21235 4333448..4335586 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IOD52_RS21240 4335943..4336686 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IOD52_RS21245 4336689..4336862 - 174 WP_019725541.1 hypothetical protein -
IOD52_RS21250 4336947..4337255 + 309 WP_019725542.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T180365 WP_009309309.1 NZ_CP064129:4332454-4332738 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T180365 NZ_CP085193:7261717-7262091 [Streptomyces rapamycinicus NRRL 5491]
ATGCACTACCTCACCCTGCCCGAGCTGCTGAACCTCGCGGAGCGGCTCGGGGCCGACGAGGTGCGCGACTACGGGCTGCT
GGAGTCCGCGCTGGCCCGTCCGCAGGCGAGCGTGTTCGGACAGGACGCCTACCCGGACGTGTGGCAGAAGGCGGCGGCGC
TGATGGAGTCGCTGGCCCGCAACCACGCCTTGGTGGACGGCAACAAGCGCCTGTCCTGGTACGCGACCTGGGTTTTCCTC
CACATCAACGGACACCCGCTGAACGCGGACTTCGACGTCGACGAGGCCGAGCGCTTCGTGCTGAGCGTCTGCCAGGGCGA
GCTGGACGTGCCGAAGATCGCGGAGGGGCTGACCCGGTTCACCAACGGAATGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT180365 WP_002886901.1 NZ_CP064129:4332222-4332464 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT180365 NZ_CP085193:7261520-7261717 [Streptomyces rapamycinicus NRRL 5491]
ATGGCAGCACTGAACCTACGCTTTACGGACGAGGAGCTCGACGCCTTGCGCAAGCGCGCGGAGGCGGAGGGCCGGAGCAT
GCAGTCGTTCGCCCACGACGCGGTGATCGCTGCGATCAACGAGCACTCCCGGCTGTTCAACGAGGCCGCCGCCCATGTGC
TGCGGGCGAGCGAAGAGCTCAACCGGAGGCTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References