Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2980013..2980670 Replicon chromosome
Accession NZ_CP064129
Organism Klebsiella pneumoniae strain M911-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IOD52_RS14630 Protein ID WP_002916310.1
Coordinates 2980013..2980423 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IOD52_RS14635 Protein ID WP_002916312.1
Coordinates 2980404..2980670 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD52_RS14610 2976013..2977746 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
IOD52_RS14615 2977752..2978465 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IOD52_RS14620 2978488..2979384 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IOD52_RS14625 2979485..2980006 + 522 WP_002916308.1 flavodoxin FldB -
IOD52_RS14630 2980013..2980423 - 411 WP_002916310.1 protein YgfX Toxin
IOD52_RS14635 2980404..2980670 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IOD52_RS14640 2980916..2981899 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IOD52_RS14645 2981998..2982657 - 660 WP_002916317.1 hemolysin III family protein -
IOD52_RS14650 2982821..2983132 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IOD52_RS14655 2983182..2983910 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IOD52_RS14660 2984029..2985462 + 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T180359 WP_002916310.1 NZ_CP064129:c2980423-2980013 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T180359 NZ_CP085188:c4398650-4398477 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT180359 WP_002916312.1 NZ_CP064129:c2980670-2980404 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT180359 NZ_CP085188:c4398974-4398678 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References