Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3726510..3727182 Replicon chromosome
Accession NZ_CP064128
Organism Yersinia pestis strain M2086

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU65_RS16535 Protein ID WP_002215144.1
Coordinates 3726757..3727182 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU65_RS16530 Protein ID WP_002209939.1
Coordinates 3726510..3726776 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU65_RS16510 3722367..3723470 + 1104 WP_002209943.1 hypothetical protein -
ISU65_RS16515 3723672..3724373 + 702 WP_002209942.1 hemolysin III family protein -
ISU65_RS16520 3724631..3725128 + 498 WP_002209941.1 DUF2165 family protein -
ISU65_RS16525 3725201..3726193 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU65_RS16530 3726510..3726776 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU65_RS16535 3726757..3727182 + 426 WP_002215144.1 protein YgfX Toxin
ISU65_RS16540 3727182..3727880 + 699 WP_002209937.1 two-component system response regulator CreB -
ISU65_RS16545 3727905..3729323 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU65_RS16550 3729444..3730901 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU65_RS16555 3730991..3731509 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180349 WP_002215144.1 NZ_CP064128:3726757-3727182 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180349 NZ_CP085188:1837779-1838033 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180349 WP_002209939.1 NZ_CP064128:3726510-3726776 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180349 NZ_CP085188:1837531-1837782 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References