Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB-HicA |
| Location | 2712747..2713393 | Replicon | chromosome |
| Accession | NZ_CP064128 | ||
| Organism | Yersinia pestis strain M2086 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A3G5L3F2 |
| Locus tag | ISU65_RS12125 | Protein ID | WP_002214976.1 |
| Coordinates | 2712747..2712929 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A0U1R391 |
| Locus tag | ISU65_RS12130 | Protein ID | WP_002211129.1 |
| Coordinates | 2712974..2713393 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ISU65_RS12090 | 2708133..2708603 | + | 471 | WP_002227961.1 | flagellar basal body-associated protein FliL | - |
| ISU65_RS12095 | 2708609..2709610 | + | 1002 | WP_002211135.1 | flagellar motor switch protein FliM | - |
| ISU65_RS12100 | 2709607..2710023 | + | 417 | WP_002211134.1 | flagellar motor switch protein FliN | - |
| ISU65_RS12105 | 2710023..2710559 | + | 537 | WP_002211133.1 | flagellar biosynthetic protein FliO | - |
| ISU65_RS12110 | 2710640..2711380 | + | 741 | WP_002220494.1 | flagellar type III secretion system pore protein FliP | - |
| ISU65_RS12115 | 2711486..2711755 | + | 270 | WP_002211131.1 | flagellar biosynthesis protein FliQ | - |
| ISU65_RS12120 | 2711758..2712540 | + | 783 | WP_002211130.1 | flagellar type III secretion system protein FliR | - |
| ISU65_RS12125 | 2712747..2712929 | + | 183 | WP_002214976.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| ISU65_RS12130 | 2712974..2713393 | + | 420 | WP_002211129.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| ISU65_RS12135 | 2713651..2714610 | - | 960 | WP_002223882.1 | sugar kinase | - |
| ISU65_RS12140 | 2714659..2715681 | - | 1023 | WP_002214974.1 | ABC transporter permease | - |
| ISU65_RS12145 | 2715684..2717261 | - | 1578 | WP_002211126.1 | sugar ABC transporter ATP-binding protein | - |
| ISU65_RS12150 | 2717327..2718322 | - | 996 | WP_002211125.1 | substrate-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | fliZ / fliA / fliD / fliS / fliT / fliE / fliF / fliG / fliH / fliI / fliJ / fliL / fliM / fliN / fliP / fliQ / fliR / flgL / flgK / flgJ / flgI / flgH / flgG / flgF / flgE / flgD / flgC / flgB / flgA / flgM / flgN / flhE / flhA / flhB | 2639222..2748834 | 109612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6783.99 Da Isoelectric Point: 10.8877
>T180339 WP_002214976.1 NZ_CP064128:2712747-2712929 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS
Download Length: 183 bp
>T180339 NZ_CP085188:c49719-49342 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15549.42 Da Isoelectric Point: 4.7731
>AT180339 WP_002211129.1 NZ_CP064128:2712974-2713393 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA
Download Length: 420 bp
>AT180339 NZ_CP085188:c50143-49766 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G5L3F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1R391 |