Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1137129..1137749 Replicon chromosome
Accession NZ_CP064128
Organism Yersinia pestis strain M2086

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU65_RS04900 Protein ID WP_002208622.1
Coordinates 1137129..1137332 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU65_RS04905 Protein ID WP_002218472.1
Coordinates 1137381..1137749 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU65_RS04875 1132667..1133818 + 1152 Protein_956 ammonium transporter AmtB -
ISU65_RS04880 1134078..1134938 - 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU65_RS04885 1135195..1135716 + 522 WP_002208624.1 lipoprotein -
ISU65_RS04890 1135852..1136241 - 390 WP_002208623.1 MGMT family protein -
ISU65_RS04900 1137129..1137332 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU65_RS04905 1137381..1137749 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU65_RS04910 1137908..1138261 - 354 WP_002208619.1 hypothetical protein -
ISU65_RS04915 1139135..1139278 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU65_RS04920 1139294..1139554 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180337 WP_002208622.1 NZ_CP064128:c1137332-1137129 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180337 NZ_CP085185:c54885-54604 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180337 WP_002218472.1 NZ_CP064128:c1137749-1137381 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180337 NZ_CP085185:c55126-54875 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References