Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2944604..2945276 Replicon chromosome
Accession NZ_CP064127
Organism Yersinia pestis strain C-830

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU64_RS13350 Protein ID WP_002215144.1
Coordinates 2944604..2945029 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU64_RS13355 Protein ID WP_002209939.1
Coordinates 2945010..2945276 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU64_RS13330 2940277..2940795 + 519 WP_002209934.1 flavodoxin FldB -
ISU64_RS13335 2940885..2942342 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU64_RS13340 2942463..2943881 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU64_RS13345 2943906..2944604 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU64_RS13350 2944604..2945029 - 426 WP_002215144.1 protein YgfX Toxin
ISU64_RS13355 2945010..2945276 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU64_RS13360 2945593..2946585 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU64_RS13365 2946658..2947155 - 498 WP_002209941.1 DUF2165 family protein -
ISU64_RS13370 2947413..2948114 - 702 WP_002209942.1 hemolysin III family protein -
ISU64_RS13375 2948316..2949419 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180336 WP_002215144.1 NZ_CP064127:c2945029-2944604 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180336 NZ_CP085185:7032-7292 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180336 WP_002209939.1 NZ_CP064127:c2945276-2945010 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180336 NZ_CP085185:7282-7533 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References