Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2579604..2580250 Replicon chromosome
Accession NZ_CP064127
Organism Yersinia pestis strain C-830

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU64_RS11545 Protein ID WP_002214976.1
Coordinates 2580068..2580250 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU64_RS11540 Protein ID WP_002211129.1
Coordinates 2579604..2580023 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU64_RS11520 2574675..2575670 + 996 WP_002211125.1 substrate-binding domain-containing protein -
ISU64_RS11525 2575736..2577313 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU64_RS11530 2577316..2578338 + 1023 WP_002214974.1 ABC transporter permease -
ISU64_RS11535 2578387..2579346 + 960 WP_002211128.1 sugar kinase -
ISU64_RS11540 2579604..2580023 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU64_RS11545 2580068..2580250 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU64_RS11550 2580457..2581239 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU64_RS11555 2581242..2581511 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU64_RS11560 2581617..2582357 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU64_RS11565 2582438..2582974 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU64_RS11570 2582974..2583390 - 417 WP_054104949.1 flagellar motor switch protein FliN -
ISU64_RS11575 2583387..2584388 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU64_RS11580 2584394..2584864 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180334 WP_002214976.1 NZ_CP064127:c2580250-2580068 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180334 NZ_CP085183:c4743791-4743480 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180334 WP_002211129.1 NZ_CP064127:c2580023-2579604 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180334 NZ_CP085183:c4743479-4743189 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References