Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1805658..1806607 Replicon chromosome
Accession NZ_CP064127
Organism Yersinia pestis strain C-830

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU64_RS08090 Protein ID WP_002210981.1
Coordinates 1806149..1806607 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU64_RS08085 Protein ID WP_002210982.1
Coordinates 1805658..1806104 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU64_RS08070 1800822..1802468 - 1647 WP_002210973.1 peptide ABC transporter substrate-binding protein SapA -
ISU64_RS08075 1803140..1803598 + 459 WP_002213759.1 IS200/IS605-like element IS1541A family transposase -
ISU64_RS08080 1803745..1805322 - 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU64_RS08085 1805658..1806104 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU64_RS08090 1806149..1806607 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU64_RS08095 1806617..1807678 - 1062 WP_002210980.1 YcjF family protein -
ISU64_RS08100 1807675..1809072 - 1398 WP_011906190.1 YcjX family protein -
ISU64_RS08105 1809053..1809295 - 243 WP_002216375.1 phage shock protein PspD -
ISU64_RS08110 1809380..1809739 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU64_RS08115 1809739..1809966 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU64_RS08120 1810128..1810793 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1803140..1803598 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180325 WP_002210981.1 NZ_CP064127:1806149-1806607 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180325 NZ_CP085183:2844098-2844205 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180325 WP_002210982.1 NZ_CP064127:1805658-1806104 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180325 NZ_CP085183:c2844050-2843983 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References