Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2452884..2453530 Replicon chromosome
Accession NZ_CP064126
Organism Yersinia pestis strain I-1252

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU63_RS11040 Protein ID WP_002214976.1
Coordinates 2452884..2453066 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU63_RS11045 Protein ID WP_002211129.1
Coordinates 2453111..2453530 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU63_RS11005 2448270..2448740 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
ISU63_RS11010 2448746..2449747 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU63_RS11015 2449744..2450160 + 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU63_RS11020 2450160..2450696 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU63_RS11025 2450777..2451517 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU63_RS11030 2451623..2451892 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU63_RS11035 2451895..2452677 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU63_RS11040 2452884..2453066 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU63_RS11045 2453111..2453530 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU63_RS11050 2453788..2454747 - 960 WP_002223882.1 sugar kinase -
ISU63_RS11055 2454796..2455818 - 1023 WP_002214974.1 ABC transporter permease -
ISU63_RS11060 2455821..2457398 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU63_RS11065 2457464..2458459 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180314 WP_002214976.1 NZ_CP064126:2452884-2453066 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180314 NZ_CP085183:295003-295278 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180314 WP_002211129.1 NZ_CP064126:2453111-2453530 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180314 NZ_CP085183:295275-295634 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References