Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1889744..1890710 Replicon chromosome
Accession NZ_CP064126
Organism Yersinia pestis strain I-1252

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU63_RS08455 Protein ID WP_002210981.1
Coordinates 1889744..1890202 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU63_RS08460 Protein ID WP_002210982.1
Coordinates 1890264..1890710 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU63_RS08425 1885558..1886223 + 666 WP_002210975.1 phage shock protein PspA -
ISU63_RS08430 1886385..1886612 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU63_RS08435 1886612..1886971 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU63_RS08440 1887056..1887298 + 243 WP_002216375.1 phage shock protein PspD -
ISU63_RS08445 1887279..1888676 + 1398 WP_002210979.1 YcjX family protein -
ISU63_RS08450 1888673..1889734 + 1062 WP_002210980.1 YcjF family protein -
ISU63_RS08455 1889744..1890202 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU63_RS08460 1890264..1890710 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU63_RS08465 1891046..1892623 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU63_RS08470 1892770..1893228 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU63_RS08475 1893481..1893984 - 504 WP_002210984.1 thiol peroxidase -
ISU63_RS08480 1894147..1895121 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1892770..1893228 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180313 WP_002210981.1 NZ_CP064126:c1890202-1889744 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180313 NZ_CP085169:205742-206053 [Sulfitobacter sp. DSM 110093]
ATGACCTACATCCCAGAGGCAGGCGACATCGTCTGGCTGCAATTCAACCCACAAGCAGGACACCGTCCAGCGCTCGTCTT
GAGCCCAGCAAAGTACAATAAGATCGGCTTGATGCTCTGCTGCCCGATGACGACCAAAGTAAAGGGATACCCCTTCGAAG
TGGTTATCAAAGGGTCGCCGATTAGCGCAGCGCTTGCTGATCAAGTGGAAAGCCTGGATTGGAAAGTCAGAAGAGCAAAG
CGGAAGGGTCAGGTAACCATATCGGAACTAGCAGAAGTGCGCGCCAAGTCCGTTGCGCTCATCAAGGGCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180313 WP_002210982.1 NZ_CP064126:c1890710-1890264 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180313 NZ_CP085169:205498-205740 [Sulfitobacter sp. DSM 110093]
ATGCGCGTGATAGTGAAAAAATGGGGCAATAGTGCCTCCGTTCGGATACCTGCAGCCATTATGCAGGCAGCGAAGCTATC
GCTCGATACTCCTGTTGATGTACGCGAAGAAAATGGACGTATTATCATTGAGCCAGATCGATCGCCGGAGTTTCTATTGG
ACGATTTGTTAAATGGAATTACCAGCGATAATGCTCATGCATCAATCAAGACTGGTGGGCCATTGGGGCAAGAAACCTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References