Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3472738..3473410 | Replicon | chromosome |
Accession | NZ_CP064125 | ||
Organism | Yersinia pestis strain M2085 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | Q666S4 |
Locus tag | ISU62_RS15540 | Protein ID | WP_002215144.1 |
Coordinates | 3472738..3473163 (-) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | Q666S3 |
Locus tag | ISU62_RS15545 | Protein ID | WP_002209939.1 |
Coordinates | 3473144..3473410 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ISU62_RS15520 | 3468390..3468908 | + | 519 | WP_002209934.1 | flavodoxin FldB | - |
ISU62_RS15525 | 3468998..3470455 | - | 1458 | WP_002220113.1 | cell envelope integrity protein CreD | - |
ISU62_RS15530 | 3470597..3472015 | - | 1419 | WP_002209936.1 | two-component system sensor histidine kinase CreC | - |
ISU62_RS15535 | 3472040..3472738 | - | 699 | WP_002209937.1 | two-component system response regulator CreB | - |
ISU62_RS15540 | 3472738..3473163 | - | 426 | WP_002215144.1 | protein YgfX | Toxin |
ISU62_RS15545 | 3473144..3473410 | - | 267 | WP_002209939.1 | FAD assembly factor SdhE | Antitoxin |
ISU62_RS15550 | 3473727..3474719 | + | 993 | WP_002209940.1 | tRNA-modifying protein YgfZ | - |
ISU62_RS15555 | 3474792..3475289 | - | 498 | WP_002209941.1 | DUF2165 family protein | - |
ISU62_RS15560 | 3475547..3476248 | - | 702 | WP_002209942.1 | hemolysin III family protein | - |
ISU62_RS15565 | 3476450..3477553 | - | 1104 | WP_002209943.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 16510.43 Da Isoelectric Point: 10.3799
>T180310 WP_002215144.1 NZ_CP064125:c3473163-3472738 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM
Download Length: 426 bp
>T180310 NZ_CP085168:260812-261123 [Sulfitobacter sp. DSM 110093]
ATGACCTACATCCCAGAGGCAGGCGACATCGTCTGGCTGCAATTCAACCCACAAGCAGGACACCGTCCAGCGCTCGTCTT
GAGCCCAGCAAAGTACAATAAGATCGGCTTGATGCTCTGCTGCCCGATGACGACCAAAGTAAAGGGATACCCCTTCGAAG
TGGTTATCAAAGGGTCGCCGATTAGCGCAGCGCTTGCTGATCAAGTGGAAAGCCTGGATTGGAAAGTCAGAAGAGCAAAG
CGGAAGGGTCAGGTAACCATATCGGAACTAGCAGAAGTGCGCGCCAAGTCCGTTGCGCTCATCAAGGGCTGA
ATGACCTACATCCCAGAGGCAGGCGACATCGTCTGGCTGCAATTCAACCCACAAGCAGGACACCGTCCAGCGCTCGTCTT
GAGCCCAGCAAAGTACAATAAGATCGGCTTGATGCTCTGCTGCCCGATGACGACCAAAGTAAAGGGATACCCCTTCGAAG
TGGTTATCAAAGGGTCGCCGATTAGCGCAGCGCTTGCTGATCAAGTGGAAAGCCTGGATTGGAAAGTCAGAAGAGCAAAG
CGGAAGGGTCAGGTAACCATATCGGAACTAGCAGAAGTGCGCGCCAAGTCCGTTGCGCTCATCAAGGGCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10511.98 Da Isoelectric Point: 4.6533
>AT180310 WP_002209939.1 NZ_CP064125:c3473410-3473144 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM
Download Length: 267 bp
>AT180310 NZ_CP085168:260568-260810 [Sulfitobacter sp. DSM 110093]
ATGCGCGTGATAGTGAAAAAATGGGGCAATAGTGCCTCCGTTCGGATACCTGCAGCCATTATGCAGGCAGCGAAGCTATC
GCTCGATACTCCTGTTGATGTACGCGAAGAAAATGGACGTATTATCATTGAGCCAGATCGATCGCCGGAGTTTCTATTGG
ACGATTTGTTAAATGGAATTACCAGCGATAATGCTCATGCATCAATCAAGACTGGTGGGCCATTGGGGCAAGAAACCTTC
TGA
ATGCGCGTGATAGTGAAAAAATGGGGCAATAGTGCCTCCGTTCGGATACCTGCAGCCATTATGCAGGCAGCGAAGCTATC
GCTCGATACTCCTGTTGATGTACGCGAAGAAAATGGACGTATTATCATTGAGCCAGATCGATCGCCGGAGTTTCTATTGG
ACGATTTGTTAAATGGAATTACCAGCGATAATGCTCATGCATCAATCAAGACTGGTGGGCCATTGGGGCAAGAAACCTTC
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q666S4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E8XP12 |