Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3472738..3473410 Replicon chromosome
Accession NZ_CP064125
Organism Yersinia pestis strain M2085

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU62_RS15540 Protein ID WP_002215144.1
Coordinates 3472738..3473163 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU62_RS15545 Protein ID WP_002209939.1
Coordinates 3473144..3473410 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU62_RS15520 3468390..3468908 + 519 WP_002209934.1 flavodoxin FldB -
ISU62_RS15525 3468998..3470455 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU62_RS15530 3470597..3472015 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU62_RS15535 3472040..3472738 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU62_RS15540 3472738..3473163 - 426 WP_002215144.1 protein YgfX Toxin
ISU62_RS15545 3473144..3473410 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU62_RS15550 3473727..3474719 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU62_RS15555 3474792..3475289 - 498 WP_002209941.1 DUF2165 family protein -
ISU62_RS15560 3475547..3476248 - 702 WP_002209942.1 hemolysin III family protein -
ISU62_RS15565 3476450..3477553 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-133)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180310 WP_002215144.1 NZ_CP064125:c3473163-3472738 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180310 NZ_CP085168:260812-261123 [Sulfitobacter sp. DSM 110093]
ATGACCTACATCCCAGAGGCAGGCGACATCGTCTGGCTGCAATTCAACCCACAAGCAGGACACCGTCCAGCGCTCGTCTT
GAGCCCAGCAAAGTACAATAAGATCGGCTTGATGCTCTGCTGCCCGATGACGACCAAAGTAAAGGGATACCCCTTCGAAG
TGGTTATCAAAGGGTCGCCGATTAGCGCAGCGCTTGCTGATCAAGTGGAAAGCCTGGATTGGAAAGTCAGAAGAGCAAAG
CGGAAGGGTCAGGTAACCATATCGGAACTAGCAGAAGTGCGCGCCAAGTCCGTTGCGCTCATCAAGGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180310 WP_002209939.1 NZ_CP064125:c3473410-3473144 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180310 NZ_CP085168:260568-260810 [Sulfitobacter sp. DSM 110093]
ATGCGCGTGATAGTGAAAAAATGGGGCAATAGTGCCTCCGTTCGGATACCTGCAGCCATTATGCAGGCAGCGAAGCTATC
GCTCGATACTCCTGTTGATGTACGCGAAGAAAATGGACGTATTATCATTGAGCCAGATCGATCGCCGGAGTTTCTATTGG
ACGATTTGTTAAATGGAATTACCAGCGATAATGCTCATGCATCAATCAAGACTGGTGGGCCATTGGGGCAAGAAACCTTC
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q666S4


Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References