Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2835177..2835823 Replicon chromosome
Accession NZ_CP064125
Organism Yersinia pestis strain M2085

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU62_RS12590 Protein ID WP_002214976.1
Coordinates 2835177..2835359 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU62_RS12595 Protein ID WP_002211129.1
Coordinates 2835404..2835823 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU62_RS12555 2830563..2831033 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
ISU62_RS12560 2831039..2832040 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU62_RS12565 2832037..2832453 + 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU62_RS12570 2832453..2832989 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU62_RS12575 2833070..2833810 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU62_RS12580 2833916..2834185 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU62_RS12585 2834188..2834970 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU62_RS12590 2835177..2835359 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU62_RS12595 2835404..2835823 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU62_RS12600 2836081..2837040 - 960 WP_002211128.1 sugar kinase -
ISU62_RS12605 2837089..2838111 - 1023 WP_002214974.1 ABC transporter permease -
ISU62_RS12610 2838114..2839691 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU62_RS12615 2839757..2840752 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180300 WP_002214976.1 NZ_CP064125:2835177-2835359 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180300 NZ_CP085145:73140-73391 [Sulfitobacter dubius]
ATGGATGTTATGACCTATTCAGATGCACGAGCTCACCTGAAGGACGTCATGGATCGTGCGATCAATGATAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGTGAGTCCGTTGTGGTCGTATCCTTGGACACCTGGAACGCTGTTAACGAGACGTTGCATC
TCTTGTCCACACCGAACAACGCATCCCGCTTACGCGCTTCGATCGCGCAACTCGATGCTGGAACTGGCAATGAGCGTGAC
CTGGCCGAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180300 WP_002211129.1 NZ_CP064125:2835404-2835823 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180300 NZ_CP085145:73388-73654 [Sulfitobacter dubius]
GTGAAGCTGGTTTTTTCTGAACAGGCTTGGGAAGACTATCAACACTGGGTCAGTACCAATGACAAGGTGCATGAGCGGAT
CAACGAGCTGATTAAACAGTGCAAGCGGACCCCTTTAAAAGGGACCGGCAAGCCGGAACCTTTGAAAGGGGATCTGACCG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTCTACCGGGTCAAGAGAATGGGCGACGGTCAAAGCTTAGAG
ATTGCGCAACTGCGGTTCCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References