Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2269152..2270118 Replicon chromosome
Accession NZ_CP064125
Organism Yersinia pestis strain M2085

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU62_RS09985 Protein ID WP_002210981.1
Coordinates 2269152..2269610 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU62_RS09990 Protein ID WP_002210982.1
Coordinates 2269672..2270118 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU62_RS09955 2264966..2265631 + 666 WP_002210975.1 phage shock protein PspA -
ISU62_RS09960 2265793..2266020 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU62_RS09965 2266020..2266379 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU62_RS09970 2266464..2266706 + 243 WP_002216375.1 phage shock protein PspD -
ISU62_RS09975 2266687..2268084 + 1398 WP_002210979.1 YcjX family protein -
ISU62_RS09980 2268081..2269142 + 1062 WP_002210980.1 YcjF family protein -
ISU62_RS09985 2269152..2269610 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU62_RS09990 2269672..2270118 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU62_RS09995 2270454..2272031 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU62_RS10000 2272178..2272636 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU62_RS10005 2272889..2273392 - 504 WP_002210984.1 thiol peroxidase -
ISU62_RS10010 2273555..2274529 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2272178..2272636 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180299 WP_002210981.1 NZ_CP064125:c2269610-2269152 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180299 NZ_CP085145:c70684-70358 [Sulfitobacter dubius]
ATGGCCTACATCCCAGAGGCAGGCGACATCGTCTGGCTGCAATTCAACCCACAAGCGGGACACGAGCAAGTAGGACACCG
TCCAGCGCTCGTCTTGAGCCCAGCAAAGTACAATAAGATCGGCTTGATGCTCTGCTGCCCGATGACGACCAAAGTAAAGG
GATACCCCTTCGAAGTGGTTATCGAAGGGTCGCCGATTAGCGCAGCGCTTGCTGATCAGGTGAAAAGCCTGGATTGGAAA
GTCAGAAGAGCAAAGCGGAAGGGTCAGGTAACCATATCGGAACTAGCAGAAGTGCGCGCCAAATCCGTTGCGCTCATCAA
GGGCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180299 WP_002210982.1 NZ_CP064125:c2270118-2269672 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180299 NZ_CP085145:c70928-70686 [Sulfitobacter dubius]
ATGCGCGTGATAGTGAAAAAATGGGGCAATAGTGCCTCTGTTCGGATACCTGCAGCCATTATGCAGGCAGCGAAGCTATC
GCTCGATACTCCTGTTGATGTACGCGAAGAAAATGGACGTATTATCATTGAGCCAGATCAATCGCCGGAGTTTCTATTGG
ACGATCTGTTAAATGGCATTACCAGCGATAATGCTCATGCATCAATCGAGACTGGTGAACCATTGGGTCAAGAAACCTTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References