Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3663899..3664571 Replicon chromosome
Accession NZ_CP064124
Organism Yersinia pestis strain M-1974

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU61_RS16510 Protein ID WP_002215144.1
Coordinates 3663899..3664324 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU61_RS16515 Protein ID WP_002209939.1
Coordinates 3664305..3664571 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU61_RS16490 3659567..3660085 + 519 WP_002209934.1 flavodoxin FldB -
ISU61_RS16495 3660219..3661631 - 1413 WP_025471084.1 cell envelope integrity protein CreD -
ISU61_RS16500 3661752..3663176 - 1425 WP_002230639.1 two-component system sensor histidine kinase CreC -
ISU61_RS16505 3663201..3663899 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU61_RS16510 3663899..3664324 - 426 WP_002215144.1 protein YgfX Toxin
ISU61_RS16515 3664305..3664571 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU61_RS16520 3664888..3665880 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU61_RS16525 3665953..3666450 - 498 WP_002209941.1 DUF2165 family protein -
ISU61_RS16530 3666708..3667409 - 702 WP_002209942.1 hemolysin III family protein -
ISU61_RS16535 3667611..3668714 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180297 WP_002215144.1 NZ_CP064124:c3664324-3663899 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180297 NZ_CP085143:3776942-3777406 [Halomonas sp. NyZ770]
ATGAGCGAAGTCACCGCTTTCCGGCTGGTGAAGCGCAAGTTTCAGGAGACAGCGTTTGATGGCGATGGCGCACGGCTTTA
CGGCGGGCGCTGGAACAGCCCAGGCAATGCCTGTGTGTACGTAGCCAGCTCAGAGTCGTTGGCGCTGCTGGAAATCATGG
TGCATCTGGAAAGCTATCGGCTGCTCAATGCCTATGCGCTGCTGCGACTGACGCTGCCCAAACAGAGCATTTTGAGCGTT
GGAACGGAAGATTTACCCGAAAACTGGCGGGAAGCGCCAGCACCTGCGGAAACCGCCGACCTGGGCGATGGCTGGCTAGC
CTCCGGCCAGAGCCTGGCGCTGGCCCTGCCCAGCGTGGTGGTGCCGAGAGAGCTTAATTACATGCTCAACCCGGCCCACC
CCTTGTTCGAGCAAGCCGTTGCCAGCGCCGAGGAACTGCCGTTTCAACCCGATCCACGGCTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180297 WP_002209939.1 NZ_CP064124:c3664571-3664305 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180297 NZ_CP085143:3776496-3776945 [Halomonas sp. NyZ770]
ATGGCCGCTACCTTCTCCCAATATCAACCCACCAAAGCCGTGGCCTCCGGCTATTGGCAGCAAATTGGCCTGCCTGCGCG
AGGGCGTAAACTGCATGAGCTGCTGCATGAGGGGGTGGAGTACCGGGTCTACCCAAGGCTTGCCAAGGTGTCAGGTATCG
AGCAGAAGGCGCTGGCGCGCTATGTGGATATCCCTTCTGCCACACTGAGCCGCCGCGCCAAGTCAGGCCGCTTCAAGATG
GCGGAAAGCGACCGGCTGTATCGCTTTGCCGAGCTTTTCAAAGCAGCGCTGGACCTGTTCGAGGGTGACGCGGAGGGTGC
CCGCGCCTGGCTGCTCAAACCCAATGCCGGGCTAGGCGGACGTCGCCCCGTCGAAATGAGCGCCACCTCGGCGGAGTACC
AGACGGTACTAAACCTGATTGGACGGTTGGAGCACGGGGTGTCGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References