Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2714727..2715710 Replicon chromosome
Accession NZ_CP064124
Organism Yersinia pestis strain M-1974

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU61_RS12150 Protein ID WP_002210981.1
Coordinates 2714727..2715185 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU61_RS12155 Protein ID WP_002210982.1
Coordinates 2715264..2715710 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU61_RS12120 2710541..2711206 + 666 WP_002210975.1 phage shock protein PspA -
ISU61_RS12125 2711368..2711595 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU61_RS12130 2711595..2711954 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU61_RS12135 2712039..2712281 + 243 WP_002216375.1 phage shock protein PspD -
ISU61_RS12140 2712262..2713659 + 1398 WP_002210979.1 YcjX family protein -
ISU61_RS12145 2713656..2714717 + 1062 WP_002210980.1 YcjF family protein -
ISU61_RS12150 2714727..2715185 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU61_RS12155 2715264..2715710 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU61_RS12160 2716046..2717623 + 1578 WP_002230917.1 transcriptional regulator TyrR -
ISU61_RS12165 2717770..2718228 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU61_RS12170 2718907..2720553 + 1647 WP_002210973.1 peptide ABC transporter substrate-binding protein SapA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2717770..2718228 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180295 WP_002210981.1 NZ_CP064124:c2715185-2714727 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180295 NZ_CP085143:3069035-3069334 [Halomonas sp. NyZ770]
ATGCTCACATTCCGTATCACACCGAGAGCAAGGGACGATTTAAAAGATATCGGCCGCTATACGGAATGGCAGTGGGGCAA
GAACCAACGGGATACCTATCTAAGGGATTTTGAAAAACGGTTTCACTGGCTCGCAGAAAATCCCCTGCCAGGAAGGCATC
GCCCAGATATCAAAGAGGGTTATTTTAGCTACCCTCAAGGCCAGCACGTTATTTTTTATCTGATTGGCCATGAATGCATT
GAAATCATTGGCATTCCTCATAAAGAGATGGATATCGTTTCCTATTTTCTGACTGATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180295 WP_002210982.1 NZ_CP064124:c2715710-2715264 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180295 NZ_CP085143:3068787-3069035 [Halomonas sp. NyZ770]
ATGGCAACGACTAGCCTTAGCCTAGGAGAACACTGGGAAGCCTTCATCAAAAACGAAGTCTCTAGCGGTCGCTACGGCTC
CGCAAGTGAGGTGGTGCGGGATGCATTACGTGCCATGGAAGAACGCAAAAGCAAACTTGAGGCGCTACGTACGCACCTAG
CCCAAGGTGCCGAGCAAGCGAGCGCTGGTGAATTCGTGGACGATTTCTCAATGGATGCATTAATCAGCGATTTGGATAAC
GAATCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References