Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1051976..1052596 Replicon chromosome
Accession NZ_CP064124
Organism Yersinia pestis strain M-1974

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU61_RS04855 Protein ID WP_002208622.1
Coordinates 1052393..1052596 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU61_RS04850 Protein ID WP_002218472.1
Coordinates 1051976..1052344 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU61_RS04835 1050171..1050431 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
ISU61_RS04840 1050447..1050590 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU61_RS04845 1051464..1051817 + 354 WP_002208619.1 hypothetical protein -
ISU61_RS04850 1051976..1052344 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU61_RS04855 1052393..1052596 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU61_RS04865 1053484..1053873 + 390 WP_002208623.1 MGMT family protein -
ISU61_RS04870 1054009..1054530 - 522 WP_002208624.1 lipoprotein -
ISU61_RS04875 1054787..1055647 + 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU61_RS04880 1055907..1057196 - 1290 WP_002228344.1 ammonium transporter AmtB -
ISU61_RS04885 1057284..1057574 - 291 WP_042659203.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180294 WP_002208622.1 NZ_CP064124:1052393-1052596 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180294 NZ_CP085143:2900519-2900773 [Halomonas sp. NyZ770]
ATGAAGCTCATCTTTTCCGAGAACGCCTGGGAAGACTATTTGTACTGGCAGAAAACTGACAAAAAGATTCTCAACCGAAT
CAACAAGCTAATCAAAGAAATCAAGCGAGAGCCATTTGAAGGAGTCGGCAAGCCAGAACCCCTTAAACACAGCCTCGCGG
GTTACTGGTCTCGGCGAATCAACGAAGAACACCGCATCGTTTACAAGGTCACGGACGATGCTTTGCTTGTTGCCCAACTG
CGGTATCACTACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180294 WP_002218472.1 NZ_CP064124:1051976-1052344 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180294 NZ_CP085143:2900271-2900522 [Halomonas sp. NyZ770]
ATGGATGCCATCAGCTACACCGCCGCTAGAACCAACCTAGCAAAAACCATGGAGCGGGTCTGTGAAGACCACTCTCCTGT
GATCATCACCCGCAATAAGGCGCAATCCGTGGTCATGATCTCTCTCGAAGACTATGAAGCGCTGCAAGAGACAGCCTACC
TCCTGCGCGCGCCCAAAAACGCCCGCCGTTTACTGGAATCCGTTGCCGAGTTGGAGCAAGGGGGCGGTCAGGAAAAGGAG
CTTCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References