Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3315370..3316042 Replicon chromosome
Accession NZ_CP064123
Organism Yersinia pestis strain M2029

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU60_RS14720 Protein ID WP_002215144.1
Coordinates 3315617..3316042 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU60_RS14715 Protein ID WP_002209939.1
Coordinates 3315370..3315636 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU60_RS14695 3311227..3312330 + 1104 WP_002209943.1 hypothetical protein -
ISU60_RS14700 3312532..3313233 + 702 WP_002209942.1 hemolysin III family protein -
ISU60_RS14705 3313491..3313988 + 498 WP_002209941.1 DUF2165 family protein -
ISU60_RS14710 3314061..3315053 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU60_RS14715 3315370..3315636 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU60_RS14720 3315617..3316042 + 426 WP_002215144.1 protein YgfX Toxin
ISU60_RS14725 3316042..3316740 + 699 WP_002209937.1 two-component system response regulator CreB -
ISU60_RS14730 3316765..3318183 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU60_RS14735 3318304..3319761 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU60_RS14740 3319851..3320369 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180283 WP_002215144.1 NZ_CP064123:3315617-3316042 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180283 NZ_CP085096:c1589045-1588746 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180283 WP_002209939.1 NZ_CP064123:3315370-3315636 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180283 NZ_CP085096:c1588749-1588453 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References