Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2466877..2467523 Replicon chromosome
Accession NZ_CP064123
Organism Yersinia pestis strain M2029

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU60_RS11075 Protein ID WP_002214976.1
Coordinates 2466877..2467059 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU60_RS11080 Protein ID WP_002211129.1
Coordinates 2467104..2467523 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU60_RS11040 2462263..2462733 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
ISU60_RS11045 2462739..2463740 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU60_RS11050 2463737..2464153 + 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU60_RS11055 2464153..2464689 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU60_RS11060 2464770..2465510 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU60_RS11065 2465616..2465885 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU60_RS11070 2465888..2466670 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU60_RS11075 2466877..2467059 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU60_RS11080 2467104..2467523 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU60_RS11085 2467781..2468740 - 960 WP_002211128.1 sugar kinase -
ISU60_RS11090 2468789..2469811 - 1023 WP_002214974.1 ABC transporter permease -
ISU60_RS11095 2469814..2471391 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU60_RS11100 2471457..2472452 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180274 WP_002214976.1 NZ_CP064123:2466877-2467059 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180274 NZ_CP085095:1891267-1891518 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180274 WP_002211129.1 NZ_CP064123:2467104-2467523 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180274 NZ_CP085095:1891515-1891769 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References