Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1903388..1904354 Replicon chromosome
Accession NZ_CP064123
Organism Yersinia pestis strain M2029

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU60_RS08495 Protein ID WP_002210981.1
Coordinates 1903388..1903846 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU60_RS08500 Protein ID WP_002210982.1
Coordinates 1903908..1904354 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU60_RS08465 1899202..1899867 + 666 WP_002210975.1 phage shock protein PspA -
ISU60_RS08470 1900029..1900256 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU60_RS08475 1900256..1900615 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU60_RS08480 1900700..1900942 + 243 WP_002216375.1 phage shock protein PspD -
ISU60_RS08485 1900923..1902320 + 1398 WP_002210979.1 YcjX family protein -
ISU60_RS08490 1902317..1903378 + 1062 WP_002210980.1 YcjF family protein -
ISU60_RS08495 1903388..1903846 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU60_RS08500 1903908..1904354 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU60_RS08505 1904690..1906267 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU60_RS08510 1906414..1906872 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU60_RS08515 1907125..1907628 - 504 WP_002210984.1 thiol peroxidase -
ISU60_RS08520 1907791..1908765 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1906414..1906872 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180273 WP_002210981.1 NZ_CP064123:c1903846-1903388 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180273 NZ_CP085095:1527202-1527480 [Aggregatibacter actinomycetemcomitans]
ATGATTTTATCTTTCAAACATAAGGGACTTGAACAATTTTTTAAAACCGGTTCGACCGCAGGAATTCAAGCCAAACACGC
CAAGAAATTAAATCTGCAATTGGCCACATTAAATAATGCGGAAACGCCTCTTGCTATGAGTGTTCCCAGCTGGAATTTGC
ACAAACTTAAAGGTGATTTGCAAGAGCATTGGGCAGTTACCGTAAACGGAAATTGGCGCTTAACATTTAAATTTGAAAAT
GGTCATGCTGAAGTTGTTGATTATCAGGATTATCATTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180273 WP_002210982.1 NZ_CP064123:c1904354-1903908 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180273 NZ_CP085095:1527496-1527768 [Aggregatibacter actinomycetemcomitans]
ATGCACAATCCTCCATACCCGGGAGAACTGTTAAAAGAATATATTGATGGCGTGAGTGTCACGAAGGTTGCCCAAAAATT
AGGTGTTTCGCGTGTTACGCTTTCCCGCATTCTTAATGGGAAAGCAAGTATAACGCCTGAAATGGCTGTGCGATTAAGCG
AATTATTGAATACCACAACACCGAAATTATGGCTGGGTATGCAAGCAGACTACGATTTATGGCAAATTGAACAACAACAC
GCCGTATTCAACATCCAACCATTATTTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References