Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 889326..889946 Replicon chromosome
Accession NZ_CP064123
Organism Yersinia pestis strain M2029

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU60_RS03900 Protein ID WP_002208622.1
Coordinates 889326..889529 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU60_RS03905 Protein ID WP_002218472.1
Coordinates 889578..889946 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU60_RS03870 884348..884686 + 339 WP_002208627.1 P-II family nitrogen regulator -
ISU60_RS03875 884726..886015 + 1290 WP_002228344.1 ammonium transporter AmtB -
ISU60_RS03880 886275..887135 - 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU60_RS03885 887392..887913 + 522 WP_002208624.1 lipoprotein -
ISU60_RS03890 888049..888438 - 390 WP_002208623.1 MGMT family protein -
ISU60_RS03900 889326..889529 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU60_RS03905 889578..889946 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU60_RS03910 890105..890458 - 354 WP_002208619.1 hypothetical protein -
ISU60_RS03915 891332..891475 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU60_RS03920 891491..891751 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180272 WP_002208622.1 NZ_CP064123:c889529-889326 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180272 NZ_CP085095:c1330444-1330178 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180272 WP_002218472.1 NZ_CP064123:c889946-889578 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180272 NZ_CP085095:c1330728-1330456 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References