Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2387999..2388965 Replicon chromosome
Accession NZ_CP064122
Organism Yersinia pestis strain M-1770

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU59_RS10470 Protein ID WP_002210981.1
Coordinates 2388507..2388965 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU59_RS10465 Protein ID WP_002210982.1
Coordinates 2387999..2388445 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU59_RS10445 2383588..2384562 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
ISU59_RS10450 2384725..2385228 + 504 WP_002210984.1 thiol peroxidase -
ISU59_RS10455 2385481..2385939 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU59_RS10460 2386086..2387663 - 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU59_RS10465 2387999..2388445 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU59_RS10470 2388507..2388965 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU59_RS10475 2388975..2390036 - 1062 WP_002210980.1 YcjF family protein -
ISU59_RS10480 2390033..2391430 - 1398 WP_002210979.1 YcjX family protein -
ISU59_RS10485 2391411..2391653 - 243 WP_002216375.1 phage shock protein PspD -
ISU59_RS10490 2391738..2392097 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU59_RS10495 2392097..2392324 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU59_RS10500 2392486..2393151 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2385481..2385939 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180270 WP_002210981.1 NZ_CP064122:2388507-2388965 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180270 NZ_CP085095:1276342-1276692 [Aggregatibacter actinomycetemcomitans]
ATGTGGGCGGTGATTTTAACGGAACGATTTGAAACTTGGTTAAATCAACAGCCGATAAAAACGCAGGAATGTGTTTTGGC
AAACTTGGTACGGTTGGAACATTTTGGTCCGAATTTAGCCCGTCCTTATGTAGATAGCGTAGCAGGGTCAATTCATAGCA
ACATGAAAGAACTACGCGTTCAGCATTCGGGAAGAGCAATTCGACTCTTTTTTGCTTTTGATCCAAAGCGTAGAGCCATT
GTTTTATGTGGTGGAGATAAAGGCAATGACAAGCGGTTTTACCGTACGATGATTAGAATTGCAGATCAAGAATTGAATCA
TTATTTGGCAACCATGGAGCAAACAAAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180270 WP_002210982.1 NZ_CP064122:2387999-2388445 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180270 NZ_CP085095:1276689-1276988 [Aggregatibacter actinomycetemcomitans]
ATGAAAACATTACAACAAGTTATTGATGAACGTTCGGTAGAAAGCCGCCAACGTATTCAAACCATGGCGGAAGATTTAAT
TCTTGAAACCGGTTTGCAACTGTTGCGAGAAGAATTAAATATATCGCAACAACAATTAGCTACGATTTTAGGTGTAACTC
AACCTGCAATTAATCAACTGGAACAGCGTGGCAATGAAATTAAGCTTGCAACCCTCAAACGTTACATCGAAGCAATGGGC
GGCAAATTACGCCTTAGTGTAGAAATGCCTGATGGACATCAGCGGGTTTTTCAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References