Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1823128..1823774 Replicon chromosome
Accession NZ_CP064122
Organism Yersinia pestis strain M-1770

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU59_RS07865 Protein ID WP_002214976.1
Coordinates 1823592..1823774 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU59_RS07860 Protein ID WP_002211129.1
Coordinates 1823128..1823547 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU59_RS07840 1818199..1819194 + 996 WP_002211125.1 substrate-binding domain-containing protein -
ISU59_RS07845 1819260..1820837 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU59_RS07850 1820840..1821862 + 1023 WP_002214974.1 ABC transporter permease -
ISU59_RS07855 1821911..1822870 + 960 WP_002211128.1 sugar kinase -
ISU59_RS07860 1823128..1823547 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU59_RS07865 1823592..1823774 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU59_RS07870 1823981..1824763 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU59_RS07875 1824766..1825035 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU59_RS07880 1825141..1825881 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU59_RS07885 1825962..1826498 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU59_RS07890 1826498..1826914 - 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU59_RS07895 1826911..1827912 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU59_RS07900 1827918..1828388 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180269 WP_002214976.1 NZ_CP064122:c1823774-1823592 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180269 NZ_CP085095:c1200921-1200583 [Aggregatibacter actinomycetemcomitans]
ATGGCGAAAGCTCACAAATGGCCGACGGAATTTCAATATCCCCCAAAATGGCTTGATTCTGCGCGCTCCCGTCCAATTTC
ATTATCATTGCCTTTATCCCATAAAGTTTACCGAGAGGATTCGGTTTACAATTTCTTCGATAATCTTTTGCCCGACAATG
AACAAATTCGTTCACGCATTCAGCAACGTTTCCAGACCTCGACCAAATCCCCCTTTGATTTGCTTTCGGCTATTGAGCAG
GATTGCGTTGGGGCGATTCAACTTTATCACGGTGAAAGTCGCTCTGTTCGGCAAATTTATACGGAGCCGTTAAATGATAA
GAAGTGTAAAACGTGTTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180269 WP_002211129.1 NZ_CP064122:c1823547-1823128 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180269 NZ_CP085095:c1201252-1200971 [Aggregatibacter actinomycetemcomitans]
ATGGTTATTACCACCGCAAAAATGCTTTCTCATGTTATTCGGGAATTTCGTTATCAAGGCAACCTCTCACAAACAGATGT
CGCCAAGCTTGCTAGCACCACCCAAGCCAGAATATCGGTTTTTGAAAATGAGCCGGAACGCACGAAATTAGAAACGTTAT
TTAAAATTTTGGCAGGATTAGAGTTAGAACTTATCGTACAACCGCGCAAAAAATCCGCGGTTACGGAAAATTTAATCAGC
GAACCAACACCTGCATTTTCCGATGACGATGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References