Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811315..811987 Replicon chromosome
Accession NZ_CP064122
Organism Yersinia pestis strain M-1770

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU59_RS03460 Protein ID WP_002215144.1
Coordinates 811315..811740 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU59_RS03465 Protein ID WP_002209939.1
Coordinates 811721..811987 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU59_RS03440 806967..807485 + 519 WP_002209934.1 flavodoxin FldB -
ISU59_RS03445 807575..809032 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU59_RS03450 809174..810592 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU59_RS03455 810617..811315 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU59_RS03460 811315..811740 - 426 WP_002215144.1 protein YgfX Toxin
ISU59_RS03465 811721..811987 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU59_RS03470 812304..813296 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU59_RS03475 813369..813866 - 498 WP_002209941.1 DUF2165 family protein -
ISU59_RS03480 814124..814825 - 702 WP_002209942.1 hemolysin III family protein -
ISU59_RS03485 815027..816130 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180259 WP_002215144.1 NZ_CP064122:c811740-811315 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180259 NZ_CP085094:c1200921-1200583 [Aggregatibacter actinomycetemcomitans]
ATGGCGAAAGCTCACAAATGGCCGACGGAATTTCAATATCCCCCAAAATGGCTTGATTCTGCGCGCTCCCGTCCAATTTC
ATTATCATTGCCTTTATCCCATAAAGTTTACCGAGAGGATTCGGTTTACAATTTCTTCGATAATCTTTTGCCCGACAATG
AACAAATTCGTTCACGCATTCAGCAACGTTTCCAGACCTCGACCAAATCCCCCTTTGATTTGCTTTCGGCTATTGAGCAG
GATTGCGTTGGGGCGATTCAACTTTATCACGGTGAAAGTCGCTCTGTTCGGCAAATTTATACGGAGCCGTTAAATGATAA
GAAGTGTAAAACGTGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180259 WP_002209939.1 NZ_CP064122:c811987-811721 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180259 NZ_CP085094:c1201252-1200971 [Aggregatibacter actinomycetemcomitans]
ATGGTTATTACCACCGCAAAAATGCTTTCTCATGTTATTCGGGAATTTCGTTATCAAGGCAACCTCTCACAAACAGATGT
CGCCAAGCTTGCTAGCACCACCCAAGCCAGAATATCGGTTTTTGAAAATGAGCCGGAACGCACGAAATTAGAAACGTTAT
TTAAAATTTTGGCAGGATTAGAGTTAGAACTTATCGTACAACCGCGCAAAAAATCCGCGGTTACGGAAAATTTAATCAGC
GAACCAACACCTGCATTTTCCGATGACGATGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References