Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2193471..2194117 Replicon chromosome
Accession NZ_CP064121
Organism Yersinia pestis strain M-1482

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU58_RS10065 Protein ID WP_002214976.1
Coordinates 2193471..2193653 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU58_RS10070 Protein ID WP_002211129.1
Coordinates 2193698..2194117 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU58_RS10030 2188857..2189327 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
ISU58_RS10035 2189333..2190334 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU58_RS10040 2190331..2190747 + 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU58_RS10045 2190747..2191283 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU58_RS10050 2191364..2192104 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU58_RS10055 2192210..2192479 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU58_RS10060 2192482..2193264 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU58_RS10065 2193471..2193653 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU58_RS10070 2193698..2194117 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU58_RS10075 2194375..2195334 - 960 WP_002223882.1 sugar kinase -
ISU58_RS10080 2195383..2196405 - 1023 WP_002214974.1 ABC transporter permease -
ISU58_RS10085 2196408..2197985 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU58_RS10090 2198051..2199046 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180248 WP_002214976.1 NZ_CP064121:2193471-2193653 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180248 NZ_CP085093:1163366-1163662 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180248 WP_002211129.1 NZ_CP064121:2193698-2194117 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180248 NZ_CP085093:1163070-1163369 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References