Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1628352..1629318 Replicon chromosome
Accession NZ_CP064121
Organism Yersinia pestis strain M-1482

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU58_RS07465 Protein ID WP_002210981.1
Coordinates 1628352..1628810 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU58_RS07470 Protein ID WP_002210982.1
Coordinates 1628872..1629318 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU58_RS07435 1624166..1624831 + 666 WP_002210975.1 phage shock protein PspA -
ISU58_RS07440 1624993..1625220 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU58_RS07445 1625220..1625579 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU58_RS07450 1625664..1625906 + 243 WP_002216375.1 phage shock protein PspD -
ISU58_RS07455 1625887..1627284 + 1398 WP_002210979.1 YcjX family protein -
ISU58_RS07460 1627281..1628342 + 1062 WP_002210980.1 YcjF family protein -
ISU58_RS07465 1628352..1628810 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU58_RS07470 1628872..1629318 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU58_RS07475 1629654..1631231 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU58_RS07480 1631378..1631836 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU58_RS07485 1632089..1632592 - 504 WP_002210984.1 thiol peroxidase -
ISU58_RS07490 1632755..1633729 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1631378..1631836 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180247 WP_002210981.1 NZ_CP064121:c1628810-1628352 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180247 NZ_CP085093:1163070-1163369 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180247 WP_002210982.1 NZ_CP064121:c1629318-1628872 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180247 NZ_CP085093:1163366-1163662 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References