Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3232160..3232780 Replicon chromosome
Accession NZ_CP064120
Organism Yersinia pestis strain KM 567

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU57_RS14445 Protein ID WP_002208622.1
Coordinates 3232577..3232780 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU57_RS14440 Protein ID WP_002218472.1
Coordinates 3232160..3232528 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU57_RS14425 3230355..3230615 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
ISU57_RS14430 3230631..3230774 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU57_RS14435 3231648..3232001 + 354 WP_002208619.1 hypothetical protein -
ISU57_RS14440 3232160..3232528 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU57_RS14445 3232577..3232780 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU57_RS14455 3233668..3234057 + 390 WP_002208623.1 MGMT family protein -
ISU57_RS14460 3234193..3234714 - 522 WP_002208624.1 lipoprotein -
ISU57_RS14465 3234971..3235831 + 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU57_RS14470 3236091..3237380 - 1290 WP_002228344.1 ammonium transporter AmtB -
ISU57_RS14475 3237420..3237758 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180245 WP_002208622.1 NZ_CP064120:3232577-3232780 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180245 NZ_CP085092:1867150-1867404 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180245 WP_002218472.1 NZ_CP064120:3232160-3232528 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180245 NZ_CP085092:1866902-1867153 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References