Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2857520..2858166 Replicon chromosome
Accession NZ_CP064120
Organism Yersinia pestis strain KM 567

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU57_RS12640 Protein ID WP_002214976.1
Coordinates 2857520..2857702 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU57_RS12645 Protein ID WP_002211129.1
Coordinates 2857747..2858166 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU57_RS12605 2852906..2853376 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
ISU57_RS12610 2853382..2854383 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU57_RS12615 2854380..2854796 + 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU57_RS12620 2854796..2855332 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU57_RS12625 2855413..2856153 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU57_RS12630 2856259..2856528 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU57_RS12635 2856531..2857313 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU57_RS12640 2857520..2857702 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU57_RS12645 2857747..2858166 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU57_RS12650 2858424..2859383 - 960 WP_002223882.1 sugar kinase -
ISU57_RS12655 2859432..2860454 - 1023 WP_002214974.1 ABC transporter permease -
ISU57_RS12660 2860457..2862034 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU57_RS12665 2862100..2863095 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180236 WP_002214976.1 NZ_CP064120:2857520-2857702 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180236 NZ_CP085091:1867150-1867404 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180236 WP_002211129.1 NZ_CP064120:2857747-2858166 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180236 NZ_CP085091:1866902-1867153 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References