Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2666670..2667636 Replicon chromosome
Accession NZ_CP064120
Organism Yersinia pestis strain KM 567

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU57_RS11630 Protein ID WP_002210981.1
Coordinates 2667178..2667636 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU57_RS11625 Protein ID WP_002210982.1
Coordinates 2666670..2667116 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU57_RS11605 2662259..2663233 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
ISU57_RS11610 2663396..2663899 + 504 WP_002210984.1 thiol peroxidase -
ISU57_RS11615 2664152..2664610 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU57_RS11620 2664757..2666334 - 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU57_RS11625 2666670..2667116 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU57_RS11630 2667178..2667636 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU57_RS11635 2667646..2668707 - 1062 WP_002210980.1 YcjF family protein -
ISU57_RS11640 2668704..2670101 - 1398 WP_002210979.1 YcjX family protein -
ISU57_RS11645 2670082..2670324 - 243 WP_002216375.1 phage shock protein PspD -
ISU57_RS11650 2670409..2670768 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU57_RS11655 2670768..2670995 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU57_RS11660 2671157..2671822 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2664152..2664610 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180235 WP_002210981.1 NZ_CP064120:2667178-2667636 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180235 NZ_CP085091:1866902-1867153 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180235 WP_002210982.1 NZ_CP064120:2666670-2667116 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180235 NZ_CP085091:1867150-1867404 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References