Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 901438..902110 Replicon chromosome
Accession NZ_CP064120
Organism Yersinia pestis strain KM 567

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU57_RS03730 Protein ID WP_002215144.1
Coordinates 901685..902110 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU57_RS03725 Protein ID WP_002209939.1
Coordinates 901438..901704 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU57_RS03705 897295..898398 + 1104 WP_002209943.1 hypothetical protein -
ISU57_RS03710 898600..899301 + 702 WP_002209942.1 hemolysin III family protein -
ISU57_RS03715 899559..900056 + 498 WP_002209941.1 DUF2165 family protein -
ISU57_RS03720 900129..901121 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU57_RS03725 901438..901704 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU57_RS03730 901685..902110 + 426 WP_002215144.1 protein YgfX Toxin
ISU57_RS03735 902110..902808 + 699 WP_002209937.1 two-component system response regulator CreB -
ISU57_RS03740 902833..904251 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU57_RS03745 904372..905829 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU57_RS03750 905919..906437 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180233 WP_002215144.1 NZ_CP064120:901685-902110 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180233 NZ_CP085091:c1304615-1304349 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCATTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180233 WP_002209939.1 NZ_CP064120:901438-901704 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180233 NZ_CP085091:c1304899-1304627 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References