Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2902534..2903500 Replicon chromosome
Accession NZ_CP064119
Organism Yersinia pestis strain C-792

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU56_RS13015 Protein ID WP_002210981.1
Coordinates 2902534..2902992 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU56_RS13020 Protein ID WP_002210982.1
Coordinates 2903054..2903500 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU56_RS12985 2898348..2899013 + 666 WP_002210975.1 phage shock protein PspA -
ISU56_RS12990 2899175..2899402 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU56_RS12995 2899402..2899761 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU56_RS13000 2899846..2900088 + 243 WP_002216375.1 phage shock protein PspD -
ISU56_RS13005 2900069..2901466 + 1398 WP_002210979.1 YcjX family protein -
ISU56_RS13010 2901463..2902524 + 1062 WP_002210980.1 YcjF family protein -
ISU56_RS13015 2902534..2902992 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU56_RS13020 2903054..2903500 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU56_RS13025 2903836..2905413 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU56_RS13030 2905560..2906018 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU56_RS13035 2906271..2906774 - 504 WP_002210984.1 thiol peroxidase -
ISU56_RS13040 2906937..2907911 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2905560..2906018 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180231 WP_002210981.1 NZ_CP064119:c2902992-2902534 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180231 NZ_CP085091:c1182896-1182558 [Aggregatibacter actinomycetemcomitans]
ATGGCGAAAGCTCACAAATGGCCGACGGAATTTCAATATCCCCCAAAATGGCTTGATTCTGCGCGCTCCCGTCCAATTTC
ATTATCATTGCCTTTATCCCATAAAGTTTACCGAGAGGATTCGGTTTACAATTTCTTCGATAATCTTTTGCCCGAAAATG
AACAAATTCGTTCACGCATTCAGCAACGTTTCCAGACCTCGACCAAATCCCCCTTTGATTTGCTTTCGGCTATTGAGCAG
GATTGCGTTGGGGCGATTCAACTTTATCACGGTGAAAGTCGCTCTGTTCGGCAAATTTATGCGGAGCCGTTAAATGATAA
GAAGTGTAAAACGTGTTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180231 WP_002210982.1 NZ_CP064119:c2903500-2903054 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180231 NZ_CP085091:c1183227-1182946 [Aggregatibacter actinomycetemcomitans]
ATGGTTATTACCACCGCAAAAATGCTTTCTCATGTTATTCGGGAATTTCGTTATCAAGGCAACCTCTCACAAACAGATGT
CGCCAAGCTTGCTAGCACCACCCAAGCCAGAATATCGGTTTTTGAAAATGAGCCGGAACGCACGAAATTAGAAACGTTAT
TTAAAATTTTGGCAGGATTAGAGTTAGAACTTATCGTACAACCGCGCAAAAAATCCGCGGTTACGGAAAATTTAATCAGC
GAACCAACACCTGCATTTTCCGATGACGATGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References