Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2181493..2182139 Replicon chromosome
Accession NZ_CP064119
Organism Yersinia pestis strain C-792

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU56_RS09655 Protein ID WP_002214976.1
Coordinates 2181957..2182139 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU56_RS09650 Protein ID WP_002211129.1
Coordinates 2181493..2181912 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU56_RS09630 2176564..2177559 + 996 WP_002211125.1 substrate-binding domain-containing protein -
ISU56_RS09635 2177625..2179202 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU56_RS09640 2179205..2180227 + 1023 WP_002214974.1 ABC transporter permease -
ISU56_RS09645 2180276..2181235 + 960 WP_002211128.1 sugar kinase -
ISU56_RS09650 2181493..2181912 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU56_RS09655 2181957..2182139 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU56_RS09660 2182346..2183128 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU56_RS09665 2183131..2183400 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU56_RS09670 2183506..2184246 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU56_RS09675 2184327..2184863 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU56_RS09680 2184863..2185279 - 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU56_RS09685 2185276..2186277 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU56_RS09690 2186283..2186753 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180230 WP_002214976.1 NZ_CP064119:c2182139-2181957 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180230 NZ_CP085091:1145327-1145623 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180230 WP_002211129.1 NZ_CP064119:c2181912-2181493 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180230 NZ_CP085091:1145031-1145330 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References