Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3440444..3441116 Replicon chromosome
Accession NZ_CP064118
Organism Yersinia pestis strain C-783

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU55_RS15705 Protein ID WP_002215144.1
Coordinates 3440444..3440869 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU55_RS15710 Protein ID WP_002209939.1
Coordinates 3440850..3441116 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU55_RS15685 3436116..3436634 + 519 WP_002209934.1 flavodoxin FldB -
ISU55_RS15690 3436755..3438182 - 1428 WP_150020923.1 cell envelope integrity protein CreD -
ISU55_RS15695 3438303..3439721 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU55_RS15700 3439746..3440444 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU55_RS15705 3440444..3440869 - 426 WP_002215144.1 protein YgfX Toxin
ISU55_RS15710 3440850..3441116 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU55_RS15715 3441433..3442425 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU55_RS15720 3442498..3442995 - 498 WP_002209941.1 DUF2165 family protein -
ISU55_RS15725 3443253..3443954 - 702 WP_002209942.1 hemolysin III family protein -
ISU55_RS15730 3444156..3445259 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180219 WP_002215144.1 NZ_CP064118:c3440869-3440444 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180219 NZ_CP085089:1782327-1782617 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATACAAAAATGCAGAATTCAGACAAGCTCGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180219 WP_002209939.1 NZ_CP064118:c3441116-3440850 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180219 NZ_CP085089:1782083-1782337 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References