Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2077774..2078740 Replicon chromosome
Accession NZ_CP064118
Organism Yersinia pestis strain C-783

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU55_RS09415 Protein ID WP_002210981.1
Coordinates 2077774..2078232 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU55_RS09420 Protein ID WP_002210982.1
Coordinates 2078294..2078740 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU55_RS09385 2073588..2074253 + 666 WP_002210975.1 phage shock protein PspA -
ISU55_RS09390 2074415..2074642 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU55_RS09395 2074642..2075001 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU55_RS09400 2075086..2075328 + 243 WP_002216375.1 phage shock protein PspD -
ISU55_RS09405 2075309..2076706 + 1398 WP_002210979.1 YcjX family protein -
ISU55_RS09410 2076703..2077764 + 1062 WP_002210980.1 YcjF family protein -
ISU55_RS09415 2077774..2078232 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU55_RS09420 2078294..2078740 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU55_RS09425 2079076..2080653 + 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU55_RS09430 2080800..2080925 - 126 Protein_1825 IS200/IS605 family transposase -
ISU55_RS09435 2081012..2082034 + 1023 WP_000255944.1 IS21-like element IS100 family transposase -
ISU55_RS09440 2082034..2082813 + 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
ISU55_RS09445 2082864..2083217 - 354 WP_152329115.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180208 WP_002210981.1 NZ_CP064118:c2078232-2077774 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180208 NZ_CP085088:c1315136-1314876 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180208 WP_002210982.1 NZ_CP064118:c2078740-2078294 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180208 NZ_CP085088:c1315359-1315138 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References