Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1065314..1065934 Replicon chromosome
Accession NZ_CP064118
Organism Yersinia pestis strain C-783

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU55_RS04795 Protein ID WP_002208622.1
Coordinates 1065314..1065517 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU55_RS04800 Protein ID WP_002218472.1
Coordinates 1065566..1065934 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU55_RS04765 1060336..1060674 + 339 WP_002208627.1 P-II family nitrogen regulator -
ISU55_RS04770 1060714..1062003 + 1290 WP_002228344.1 ammonium transporter AmtB -
ISU55_RS04775 1062263..1063123 - 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU55_RS04780 1063380..1063901 + 522 WP_002208624.1 lipoprotein -
ISU55_RS04785 1064037..1064426 - 390 WP_002208623.1 MGMT family protein -
ISU55_RS04795 1065314..1065517 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU55_RS04800 1065566..1065934 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU55_RS04805 1066093..1066446 - 354 WP_002208619.1 hypothetical protein -
ISU55_RS04810 1067320..1067463 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU55_RS04815 1067479..1067739 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180207 WP_002208622.1 NZ_CP064118:c1065517-1065314 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180207 NZ_CP085088:c830441-830184 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACTTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180207 WP_002218472.1 NZ_CP064118:c1065934-1065566 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180207 NZ_CP085088:c830676-830425 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References