Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3337500..3338120 Replicon chromosome
Accession NZ_CP064117
Organism Yersinia pestis strain C-781

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag ISU54_RS14760 Protein ID WP_002208622.1
Coordinates 3337917..3338120 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag ISU54_RS14755 Protein ID WP_002218472.1
Coordinates 3337500..3337868 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU54_RS14740 3335695..3335955 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
ISU54_RS14745 3335971..3336114 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
ISU54_RS14750 3336988..3337341 + 354 WP_002208619.1 hypothetical protein -
ISU54_RS14755 3337500..3337868 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
ISU54_RS14760 3337917..3338120 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
ISU54_RS14770 3339008..3339397 + 390 WP_002208623.1 MGMT family protein -
ISU54_RS14775 3339533..3340054 - 522 WP_002208624.1 lipoprotein -
ISU54_RS14780 3340311..3341171 + 861 WP_002208625.1 acyl-CoA thioesterase II -
ISU54_RS14785 3341431..3342720 - 1290 WP_002228344.1 ammonium transporter AmtB -
ISU54_RS14790 3342760..3343098 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T180206 WP_002208622.1 NZ_CP064117:3337917-3338120 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T180206 NZ_CP085088:581636-581905 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT180206 WP_002218472.1 NZ_CP064117:3337500-3337868 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT180206 NZ_CP085088:581419-581646 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References