Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2331123..2332089 Replicon chromosome
Accession NZ_CP064117
Organism Yersinia pestis strain C-781

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag ISU54_RS10175 Protein ID WP_002210981.1
Coordinates 2331631..2332089 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag ISU54_RS10170 Protein ID WP_002210982.1
Coordinates 2331123..2331569 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU54_RS10150 2326712..2327686 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
ISU54_RS10155 2327849..2328352 + 504 WP_002210984.1 thiol peroxidase -
ISU54_RS10160 2328605..2329063 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
ISU54_RS10165 2329210..2330787 - 1578 WP_002210983.1 transcriptional regulator TyrR -
ISU54_RS10170 2331123..2331569 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
ISU54_RS10175 2331631..2332089 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
ISU54_RS10180 2332099..2333160 - 1062 WP_002210980.1 YcjF family protein -
ISU54_RS10185 2333157..2334554 - 1398 WP_002210979.1 YcjX family protein -
ISU54_RS10190 2334535..2334777 - 243 WP_002216375.1 phage shock protein PspD -
ISU54_RS10195 2334862..2335221 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
ISU54_RS10200 2335221..2335448 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
ISU54_RS10205 2335610..2336275 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2328605..2329063 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T180205 WP_002210981.1 NZ_CP064117:2331631-2332089 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T180205 NZ_CP085087:c1940212-1939883 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT180205 WP_002210982.1 NZ_CP064117:2331123-2331569 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT180205 NZ_CP085087:c1940489-1940202 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References