Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1766330..1766976 Replicon chromosome
Accession NZ_CP064117
Organism Yersinia pestis strain C-781

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag ISU54_RS07580 Protein ID WP_002214976.1
Coordinates 1766794..1766976 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag ISU54_RS07575 Protein ID WP_002211129.1
Coordinates 1766330..1766749 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU54_RS07555 1761401..1762396 + 996 WP_002211125.1 substrate-binding domain-containing protein -
ISU54_RS07560 1762462..1764039 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
ISU54_RS07565 1764042..1765064 + 1023 WP_002214974.1 ABC transporter permease -
ISU54_RS07570 1765113..1766072 + 960 WP_002223882.1 sugar kinase -
ISU54_RS07575 1766330..1766749 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ISU54_RS07580 1766794..1766976 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
ISU54_RS07585 1767183..1767965 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
ISU54_RS07590 1767968..1768237 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
ISU54_RS07595 1768343..1769083 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
ISU54_RS07600 1769164..1769700 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
ISU54_RS07605 1769700..1770116 - 417 WP_002211134.1 flagellar motor switch protein FliN -
ISU54_RS07610 1770113..1771114 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
ISU54_RS07615 1771120..1771590 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T180204 WP_002214976.1 NZ_CP064117:c1766976-1766794 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T180204 NZ_CP085087:c1939083-1938826 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT180204 WP_002211129.1 NZ_CP064117:c1766749-1766330 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT180204 NZ_CP085087:c1939345-1939085 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References