Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 66266..66903 Replicon plasmid unnamed3
Accession NZ_CP064116
Organism Enterobacter hormaechei strain IR5283

Toxin (Protein)


Gene name vagD Uniprot ID A0A9E6WXZ4
Locus tag ISU86_RS23100 Protein ID WP_032662169.1
Coordinates 66493..66903 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A9E6WTF5
Locus tag ISU86_RS23095 Protein ID WP_032662167.1
Coordinates 66266..66496 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU86_RS23070 62265..63275 + 1011 WP_015572055.1 RepB family plasmid replication initiator protein -
ISU86_RS23075 63519..63776 - 258 Protein_65 site-specific integrase -
ISU86_RS23080 63978..64754 - 777 WP_015572054.1 site-specific integrase -
ISU86_RS23085 64773..65303 - 531 WP_013087127.1 hypothetical protein -
ISU86_RS23090 65434..65724 - 291 WP_013087126.1 hypothetical protein -
ISU86_RS23095 66266..66496 + 231 WP_032662167.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ISU86_RS23100 66493..66903 + 411 WP_032662169.1 PIN domain-containing protein Toxin
ISU86_RS23105 66977..68539 + 1563 WP_032662171.1 AAA family ATPase -
ISU86_RS23110 68524..69546 + 1023 WP_032662174.1 helicase UvrD -
ISU86_RS23115 70093..71001 + 909 WP_032662179.1 HNH endonuclease -
ISU86_RS23120 71187..71537 - 351 WP_032662182.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / tet(D) - 1..79219 79219


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14729.03 Da        Isoelectric Point: 5.7351

>T180193 WP_032662169.1 NZ_CP064116:66493-66903 [Enterobacter hormaechei]
VNKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITWAEVSLASQEAGPAAQKLADAFAARLDAILPWDRTAV
DATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVR

Download         Length: 411 bp

>T180193 NZ_CP085086:760427-761203 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGAAGAGTTTCAGAAGGCCTTGCAGCGAACTATTAGGGCCCAAAGTCGTGGGAAGAC
GATTCCAAATCAACCGAGAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAT
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAAATTCAGATTTATCAAAGAGATCGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAGGTTGAGGAAGAGATGTTG
AAGGTAGGACAGGAACGGTTGGGGGAATTAGTTTCAGCTAATGGAGAGAAGAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8645.77 Da        Isoelectric Point: 4.4692

>AT180193 WP_032662167.1 NZ_CP064116:66266-66496 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMAERGDVVSDEGRVNL

Download         Length: 231 bp

>AT180193 NZ_CP085086:759951-760427 [Streptococcus suis]
ATGATTGGAGACAACATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGAACCAGCACCGTATCAACAGAACTCATCGACCGCATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACCTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATTGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References