Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 20466..21205 Replicon plasmid unnamed3
Accession NZ_CP064116
Organism Enterobacter hormaechei strain IR5283

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag ISU86_RS22855 Protein ID WP_013087269.1
Coordinates 20720..21205 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag ISU86_RS22850 Protein ID WP_007869691.1
Coordinates 20466..20732 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU86_RS22825 15533..16303 + 771 WP_013087103.1 conjugal transfer protein TraX -
ISU86_RS22830 16318..16656 + 339 WP_013087102.1 hypothetical protein -
ISU86_RS22835 16739..17068 + 330 WP_013087101.1 hypothetical protein -
ISU86_RS22840 17043..17849 - 807 WP_013087100.1 DUF4225 domain-containing protein -
ISU86_RS22845 18800..19813 - 1014 WP_013087098.1 replication initiation protein -
ISU86_RS22850 20466..20732 + 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
ISU86_RS22855 20720..21205 + 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
ISU86_RS22860 21572..22390 - 819 WP_013087268.1 abortive infection family protein -
ISU86_RS22870 23139..23969 - 831 WP_100135202.1 hypothetical protein -
ISU86_RS22875 24103..24741 - 639 WP_008786709.1 DUF2913 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / tet(D) - 1..79219 79219


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T180192 WP_013087269.1 NZ_CP064116:20720-21205 [Enterobacter hormaechei]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T180192 NZ_CP085086:558337-558597 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT180192 WP_007869691.1 NZ_CP064116:20466-20732 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT180192 NZ_CP085086:558114-558335 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References