Detailed information of TA system TA180190

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3665870..3666527
• Replicon: chromosome
• Accession: NZ_CP064113
• Organism: Enterobacter hormaechei strain IR5283

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ISU86_RS17455
• Protein ID: WP_058652631.1
• Coordinates: 3665870..3666280 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: ISU86_RS17460
• Protein ID: WP_003863437.1
• Coordinates: 3666261..3666527 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISU86_RS17435	3661868..3663601	-	1734	WP_003863445.1	single-stranded-DNA-specific exonuclease RecJ	-
ISU86_RS17440	3663607..3664320	-	714	WP_003863443.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
ISU86_RS17445	3664349..3665245	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
ISU86_RS17450	3665347..3665868	+	522	WP_003863440.1	flavodoxin FldB	-
ISU86_RS17455	3665870..3666280	-	411	WP_058652631.1	protein YgfX	Toxin
ISU86_RS17460	3666261..3666527	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
ISU86_RS17465	3666822..3667802	+	981	WP_003863435.1	tRNA-modifying protein YgfZ	-
ISU86_RS17470	3667888..3668547	-	660	WP_003863433.1	hemolysin III family protein	-
ISU86_RS17475	3668814..3669545	+	732	WP_003863431.1	MurR/RpiR family transcriptional regulator	-
ISU86_RS17480	3669662..3671095	+	1434	WP_003863430.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16367.25 Da
• Isoelectric Point: 11.6602

>T180190 WP_058652631.1 NZ_CP064113:c3666280-3665870 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIRLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T180190 NZ_CP085085:c1451308-1451048 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT180190 WP_003863437.1 NZ_CP064113:c3666527-3666261 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT180190 NZ_CP085085:c1451531-1451310 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5