Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2220640..2221379 Replicon chromosome
Accession NZ_CP064113
Organism Enterobacter hormaechei strain IR5283

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag ISU86_RS10725 Protein ID WP_003857133.1
Coordinates 2220640..2221125 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag ISU86_RS10730 Protein ID WP_003857131.1
Coordinates 2221113..2221379 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU86_RS10705 2216793..2217551 - 759 WP_058652201.1 trans-aconitate 2-methyltransferase -
ISU86_RS10710 2217636..2218220 - 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
ISU86_RS10715 2218307..2219065 + 759 WP_117308965.1 DeoR/GlpR family DNA-binding transcription regulator -
ISU86_RS10720 2219170..2220462 + 1293 WP_058652202.1 glycoside hydrolase -
ISU86_RS10725 2220640..2221125 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
ISU86_RS10730 2221113..2221379 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
ISU86_RS10735 2221443..2222372 - 930 WP_003857129.1 LysR family transcriptional regulator -
ISU86_RS10740 2222502..2223890 + 1389 WP_023314162.1 MFS transporter -
ISU86_RS10745 2223912..2224907 - 996 WP_003857125.1 DUF2891 domain-containing protein -
ISU86_RS10750 2224917..2225903 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T180180 WP_003857133.1 NZ_CP064113:c2221125-2220640 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T180180 NZ_CP064113:c2221125-2220640 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT180180 WP_003857131.1 NZ_CP064113:c2221379-2221113 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT180180 NZ_CP064113:c2221379-2221113 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References